Coenzyme Q10 (CoQ10) also known as ubiquinone, is a naturally occurring nutrient in the human body.
Commonly found in the human mitochondria, high levels of CoQ10 mostly exist in organs such as the heart, liver, and kidneys.
CoQ10 is important for energy, immunity, and acts as a lipid antioxidant to prevent free radicals and oxidative damage to cells.
With age, the production of CoQ10 can decrease substantially. Supplementation of CoQ10 may be beneficial in the elderly or those with certain medical conditions.
CoQ10 in supplemental form or conjunction with other therapies has shown potential to prevent/ treat medical conditions such as heart diseases, high blood pressure, diabetes, mitochondrial conditions, Parkinson’s disease, etc. (1).
CoQ10 supplements available in the form of powders, liquids, soft gels capsules, etc. can be bought online without a prescription. Listed here are our top 6 choices of CoQ10 supplements. Explore and choose the product that fits your needs the best.
Our Top Picks
1. Best Potency – aSquared Nutrition CoQ10 400 mg
2. Best Budget CoQ10 Supplement – Nutricost CoQ10 100mg
3. Best High Potency CoQ10 – Toniiq CoQ10 400mg
4. Best Vegan – Sports Research Vegan CoQ10 100mg with Coconut Oil
5. Best Powder – BulkSupplements Coenzyme Q10
6. Best Absorption – Qunol Ultra CoQ10
7. Best Budget – Doctor’s Best High Absorption CoQ10
Now let’s look at each of these CoQ10 supplements in detail to find out why they are considered the best in their categories.
1. Best Potency – aSquared Nutrition CoQ10 400 mg
aSquared Nutrition CoQ10 400mg capsules are designed to support heart health, brain function, and energy production. With 100 vegetable capsules in each bottle, this high-strength CoQ10 supplement is aimed at maintaining overall cardiovascular health and boosting stamina.
Benefits
• Promotes heart health and cardiovascular function.
• Enhances brain health and cognitive performance.
• Increases energy and stamina by supporting cellular energy production.
• May help reduce skin roughness and wrinkles due to its antioxidant properties.
What it Contains
Each capsule provides 400mg of CoQ10 (Ubiquinone), a naturally occurring antioxidant that supports energy production in cells. It also comes in a 100-day supply, with no unnecessary fillers.
Pros
• High potency (400mg per capsule) for optimal heart health support.
• Vegan-friendly and made in the USA.
• Great value for money with a full 100-day supply.
• Free from artificial additives.
Cons
• May require consistent use to notice significant benefits.
• A few users mention having to take more than one pill for desired effects.
Customer Feedback
Customers are overwhelmingly positive, highlighting the product’s high quality, value for money, and effectiveness in boosting energy and improving heart health. Some customers also appreciate its easy-to-swallow capsules and the absence of fillers.
Summary: An excellent CoQ10 supplement for supporting heart health, boosting energy, and maintaining overall well-being. This high-potency formula is vegan-friendly and offers exceptional value with a 100-day supply. A great choice for those looking for a reliable and effective CoQ10 supplement.
2. Best Budget CoQ10 Supplement – Nutricost CoQ10 100mg
Price: $16.95
Nutricost CoQ10 delivers 100mg of Coenzyme Q10 per capsule in a straightforward, no-fuss formula. Each bottle offers 120 vegetarian capsules designed for daily heart, cellular energy, and antioxidant support. The product is third-party tested, made in a GMP-compliant and FDA-registered facility, and offers one of the most affordable options on the market without compromising on quality.
Benefits
- Supports cardiovascular and heart health
- Promotes cellular energy and stamina
- May help manage cholesterol and statin-related fatigue
- Easy-to-swallow and gentle on the stomach
- Excellent price per serving for long-term use
What it Contains
- Coenzyme Q10 (100mg) per serving
- Other ingredients: Rice flour, hypromellose (vegetarian capsule)
- Form: Capsule
- Serving size: 1 capsule
- Servings per container: 120
Pros
- High-quality CoQ10 at a very low cost per serving
- Free from GMOs, gluten, and unnecessary fillers
- Manufactured in the USA under strict standards
- Easy dosing: just once per day
Cons
- Not the active ubiquinol form (may be less bioavailable for older adults)
- Some users mention the capsule is slightly large
Customer Feedback:
- Value for Money: Customers appreciate the great quality at a budget-friendly price, often noting that it performs as well as pricier brands.
- Effectiveness: Users report better energy, reduced chest discomfort, and improved heart health; some combine it with statins for added support.
- Ease of Use: Capsules are easy to take once daily, with no bad taste or aftereffects.
- Overall Satisfaction: Highly rated for its purity, potency, and affordability, with many long-term repeat buyers.
Best Suited For
This supplement is ideal for:
- Adults looking for a cost-effective daily CoQ10 supplement
- Individuals on statin medications seeking heart and energy support
- People who prefer clean, filler-free formulas
- Budget-conscious users needing a long-term CoQ10 option
Usage Recommendations
Take 1 capsule daily, preferably with a meal that contains fat for optimal absorption. Some users find it beneficial to take it in the morning for daytime energy. Dosage may be adjusted based on individual needs, especially under healthcare supervision.
Summary: Nutricost CoQ10 100mg stands out as a budget-friendly, high-quality option for supporting heart health and energy levels. It’s a smart choice for anyone seeking purity, simplicity, and consistent results—without paying a premium.
3. Best High Potency CoQ10 – Toniiq CoQ10 400mg
Price: $25.97
Toniiq CoQ10 delivers a highly potent 400mg of purified Coenzyme Q10 per 2-capsule serving, enhanced with MCT oil for better absorption. Each bottle contains 120 capsules (60 servings). Known for its purity (98% standardized CoQ10), this supplement is ideal for users seeking maximum strength and quality. Every batch is third-party tested and made in a GMP-certified facility in the USA.
Benefits
- Delivers ultra-high strength CoQ10 (400mg per serving)
- Formulated with MCT oil to enhance bioavailability
- Supports heart health, energy levels, and cellular vitality
- Offers superior purity (98%) and third-party testing
- May help reduce fatigue associated with statin use
What it Contains
- Coenzyme Q10 (Ubidecarenone 98%) – 400mg
- MCT Oil Powder – 400mg (50% Medium-Chain Triglycerides)
- Other ingredients: Vegetable cellulose capsule, silicon dioxide
- Serving size: 2 capsules
- Servings per container: 60
Pros
- Exceptionally high dose for those needing therapeutic support
- Enhanced absorption thanks to MCT pairing
- Lab-tested for purity, potency, and safety
- Made in the USA under strict GMP compliance
Cons
- Capsules are larger than average, which may be hard to swallow for some
- Pricier per serving compared to lower-dose options
- Mixed opinions on product freshness in long-term storage
Customer Feedback:
- Value for Money: Despite the price, customers say it’s worth it for the high dose and MCT inclusion, and a better deal than taking multiple lower-dose capsules.
- Effectiveness: Most users report that it “works well”, delivering noticeable energy boosts and cardiovascular support.
- Ease of Use: Some users say it’s easy to swallow, while others note the capsules are a bit large.
- Overall Satisfaction: Users value its potency, absorption, and lab-tested quality, although a few experienced quality issues after prolonged storage.
Best Suited For
This product is ideal for:
- Individuals needing high-dose CoQ10 for medical or energy-related reasons
- Users who want enhanced absorption through added MCT oil
- Adults on statins or with heart concerns looking for maximum support
- People who prioritize purity and third-party testing
Usage Recommendations
Take 2 capsules daily with a meal that includes healthy fats to optimize absorption. If taking other medications or CoQ10 sources, consult a healthcare provider before adjusting the dose.
Summary: Toniiq CoQ10 400mg stands out for its unmatched potency, added MCT for better absorption, and commitment to purity through third-party testing—making it the go-to choice for users who need maximum CoQ10 support.
4. Best Vegan – Sports Research Vegan CoQ10 100mg with Coconut Oil
Sports Research Vegan CoQ10 100mg with Coconut Oil offers a plant-based CoQ10 supplement designed to support heart health and cellular energy production. The inclusion of coconut oil enhances absorption, making it a highly bioavailable source of CoQ10. This supplement is vegan certified, non-GMO, and free from gluten, soy, and synthetic ingredients.
Key Benefits:
- Heart Health Support: CoQ10 plays a crucial role in promoting cardiovascular health and maintaining healthy blood pressure levels.
- Enhanced Absorption: The use of coconut oil as a carrier ensures better absorption of CoQ10, making it more effective.
- Vegan and Non-GMO: Certified vegan and non-GMO, this supplement is also free from gluten and soy, making it suitable for a wide range of dietary preferences.
Pros:
- High bioavailability with coconut oil
- Supports heart health and energy production
- Vegan certified and non-GMO
Cons:
- Some users may find the capsules large to swallow
- Requires daily intake for best results
Summary: Sports Research Vegan CoQ10 with Coconut Oil offers a highly absorbable, plant-based CoQ10 supplement that supports heart health and energy levels. Its vegan certification and non-GMO verification make it a reliable choice for those with specific dietary needs.
5. Best Powder – BulkSupplements Coenzyme Q10
Powder supplements work best for people who find it difficult to swallow pills or tablets. A quality powder supplement dissolves easily in water or liquids, leaves no chalky residues, and is more beneficial owing to direct absorption into the system.
About BulkSupplements Coenzyme Q10
BulkSupplements is a unique powder supplement that is loaded with Coenzyme Q10 to provide fortified immunity, support cardiovascular health and enable energetic brain functions.
The product is made via a fermentation process and uses Rhodobacter sphaeroides, a type of bacteria that has been proven by studies for viable CoQ10 production (2).
BulkSupplements is a prominent name in the supplement industry. They source the raw material for their Coenzyme Q10 from China which is subject to various tests for quality and purity at their FDA registered, cGMP compliant facility in the USA.
What it Contains:
Each serving size of 200 milligrams has:
- Coenzyme Q10 (Ubiquinone) – 200 mg
BulkSupplements Coenzyme Q10 is available as a pack of 10 grams or 0.35 oz. It is also available in larger-sized powder packs and as softgels for buyer’s convenience. Though the powder form is vegan, the softgels contain gelatin.
As a dietary supplement, you can take between 50 gm (1/32 tsp) to 200 gm (1/ tsp) depending on the requirement. The unflavored, easily dissolvable powder can be mixed in oil or oil-based dishes for better absorption. Some users also suggest mixing in soups, curries, or smoothies for desired results.
As a quality supplement, BulkSupplements Coenzyme Q10 does not contain any additives or added sugars for taste. Verified by third-party lab testing, it is also free from gluten, yeast, dairy, and soy making it a worthy supplement for easy and safe consumption.
The Pros:
- Highly-potent 200 mg of CoQ10 per serving
- Made using Rhodobacter sphaeroides bacterium
- No additives or added sugars
- Verified by third-party lab testing
Summary: BulkSupplements Coenzyme Q10 is an effective powder supplement free of additives, gluten, and sugars. With high potency and absorbency, it aids in vital organ functions and health for stronger immunity.
6. Best Absorption – Qunol Ultra CoQ10
Maximum absorption of an ingredient is a vital factor in choosing supplements. The formulation, process used, how well it can be assimilated by the body is the key for best absorption in a supplement.
About Qunol Ultra CoQ10
Qunol Ultra CoQ10 is a natural supplement fortified with CoQ10 and vitamin E for delivering antioxidant benefits that can protect the body from various diseases.
This unique supplement has a patent formulation with high solubility in both fat and water that claims to provide 3 times maximized absorption than other brands.
Qunol Ultra CoQ10 is manufactured and packaged in cGMP compliant facilities in the USA using domestic and imported ingredients. It contains soy but is gluten-free.
What it Contains:
Each serving of one softgel consists of:
- Calories – 7
- Vitamin E (as dl-alpha tocopheryl acetate) – 6 mg
- Coenzyme Q10 – 100 mg
Qunol Ultra CoQ10 is available as a pack of 120 softgels and can last for up to 4 months depending on use.
The recommended dosage is just one softgel daily for general well being or as advised by a health practitioner.
Qunol Ultra CoQ10 just contains powerful antioxidant ingredients for good energy and strengthened immunity. It is free from major allergens including egg, shellfish, fish, milk, wheat, tree nuts, and peanuts that adds additional safety in consumption.
The Pros:
- Combination of CoQ10 and vitamin E for proven antioxidant effects
- 100% fat and water solubility enables 3-times higher absorption
- Made in cGMP certified facilities in the USA
- Free from all major allergens except soy
Summary: Qunol Ultra CoQ10 is a supplement that provides 3-times higher absorption owing to its solubility in both fat and water. Free from most major allergens this product provides good antioxidant effects for overall immunity.
7. Best Budget – Doctor’s Best High Absorption CoQ10
Dietary CoQ10 supplements are plenty, with numerous brands offering products at low-cost prices. A dietary supplement that is pocket-friendly and yet does not compromise on quality and potency is what makes it fit into the best budget category.
About Doctor’s Best High Absorption CoQ10
Doctor’s Best High Absorption CoQ10 is a top-ranking supplement that delivers potent doses of naturally fermented CoQ10 to replace depleted levels of this nutrient in the body that may occur due to aging, use of statin drugs, or other medical conditions.
Fortified with BioPerine® piperine, a black pepper patented extract that is known to increase the bioavailability of nutrients, this supplement ensures the efficient absorption of CoQ10 for overall health (3).
Made in the USA, Doctor’s Best High Absorption CoQ10 is manufactured in cGMP-certified facilities and undergoes intensive testing right from raw-materials to finished products to assure quality to the consumer.
What it Contains:
Each serving of one softgel offer:
- Coenzyme Q10 (Ubiquinone – 100 mg
- Black Pepper Ext. (Piper nigrum) (Fruit) – 5 mg
(standardized to contain 95% Piperine)(BioPerine®)
Available as a container of 120 softgels, this product can serve as a 4-month supply which is certainly value for money.
The recommended dosage is one softgel a day with meals to ensure maximum absorption or as recommended by your doctor.
Doctor’s Best High Absorption CoQ10 contains pure, natural ingredients and does not contain gluten. Time-tested for quality, this product lasts for months and bestows immense health benefits at a highly affordable price.
The Pros:
- Only CoQ10 with added Bioperine® for absorption
- Budget-friendly price
- One container provides a 4-month supply
- Gluten-free
Summary: Doctor’s Best High Absorption CoQ10 with added piperine ensures enhanced absorption for good health. Free from gluten, this product is pocket-friendly, lasts for 4 months which is good value for your money.
Dosage for CoQ10 Supplements
CoQ10 can be obtained through food including oily fish, organ meats (heart, liver), some vegetable oils, spinach, cauliflower, orange, strawberry, legumes, and whole grains (4).
Since CoQ10 is fat-soluble, it is advantageous to consume supplements with fatty foods or meals for maximum absorption and efficiency (5).
According to studies, CoQ10 supplements in ubiquinol form may have higher bioavailability than ubiquinone (6).
Dosage for CoQ10 is normally dependent on the overall need or the medical condition for it may be prescribed by a practitioner. Studies have shown that several diseases have been identified as possibilities of CoQ10 deficiency and oral supplementation can help improve such conditions (7).
Typical dosages may vary from 30 to 200 mg a day and the highest safe intake has been estimated to be at 1200 mg/ day in scientific studies (8).
Oral supplements generally provide 100 mg or 200 mg of CoQ10 which is deemed quite safe. But to get maximum benefits, you should follow the manufacturer’s instructions or consult a practitioner for a suitable dosage.
Summary: Coenzyme Q10 can be obtained through foods as well as oral supplements. Depending on the requirement, CoQ10 supplementation can vary. It is beneficial to take supplements with food to maximize absorption.
Risks and Side Effects of Taking CoQ10 Supplements
CoQ10 is a natural substance and the human body does require it to maintain organ health, energy, and immunity. Oral supplements are beneficial and generally considered safe.
But taking CoQ10 in supplement form may involve certain risks or side effects which are given below (9).
- Mild or occasional side effects such as nausea, diarrhea, stomach upsets, vomiting have been reported from the consumption of CoQ10 supplements.
- Dizziness, heartburn, fatigue, or photophobia can occur in very rare cases.
- Doses above 100 mg may cause insomnia in some individuals
- Clinical studies have not established the effect of CoQ10 supplementation for patients with kidney or liver disease. Hence, people with such conditions should avoid these supplements.
- CoQ10 can reduce blood sugar and hence diabetics should avoid or exercise caution in using these supplements to avoid hypoglycemia.
- Pregnant, nursing, women, and children should steer clear of CoQ10 supplements as no studies are available for such people.
- CoQ10 has been known to interact with certain drugs. Individuals who are under chemotherapy, or have been prescribed blood thinners, antiplatelet, antidepressants, antihypertensive drugs should seek a practitioner’s advice before using CoQ10 supplements (10).
Summary: CoQ10 is generally safe with minimal or rare adverse effects. People taking high doses, prescribed medications, pregnant women, and those with kidney or liver disease need to consult a doctor to avoid risks or side effects from CoQ supplementation.
Frequently Asked Questions (FAQs)
Is CoQ10 Essential for our Body?
Much like certain amino acids, CoQ10 can be termed as a ‘conditionally essential’ nutrient that helps in the production of enzymes to create and regulate ATP (adenosine triphosphate) for cellular energy. Its antioxidant nature helps fight free-radical damage, oxidative stress, and boosts immunity in the body.
Vital organs such as the heart, lungs, liver, etc. demand high-energy levels for healthy functioning which would not be possible without adequate CoQ10 levels. Hence, CoQ10 is also vital for optimal cardiovascular, brain, and other organ health (11).
Which is the Ideal Form of a CoQ10 supplement?
Coenzyme Q10 is present as both ubiquinone (oxidized form) and ubiquinol (reduced form) in the human body. The human body converts ubiquinone to ubiquinol and then uses it to support metabolic functions.
Though both forms can be considered for supplementation, studies show that taking ubiquinol as supplements makes it easier for assimilation especially when it is taken to bridge age-related deficiency (12).
Who Can Take CoQ10 Supplements?
People aged 40 and above would benefit most from taking a supplement as natural CoQ10 levels tend to decrease with age.
Individuals using cholesterol-lowering statins or with certain medical conditions such as heart disease, mitochondrial disorders, hypertension, etc. will benefit through CoQ10 supplementation duly recommended by a medical practitioner.
What is the Best Time to Take CoQ10 Supplements?
CoQ10 supplements can be taken at any time of the day with food. Divided doses of CoQ10, when taken with food, may be more beneficial, as it enables full absorption and minimizes any stomach discomfort that may arise with a single large dose.
Also, it is best not to consume these supplements at night-time. Studies have indicated that CoQ10 has the potential to induce insomnia in some cases which may occur due to increased amounts of energy.
The Final Note
Coenzyme Q10 is a natural nutrient produced and used by the body to sustain energy circulation, maintain vital organ functioning, and promote immunity in the body. The deficiency of CoQ10 may occur due to age, medications, stress, etc.
Though CoQ10 can be obtained through specific kinds of food, oral supplements work better to bridge deficiencies quickly and help protect or slow the progress of various diseases.
Softgels, capsules, and powder supplements are effective choices available in different categories to serve a variety of users. Check with a doctor before using CoQ10 supplements for dosage, suitability, drug interactions, or specific medical conditions to avoid adverse effects.
Using CoQ10 supplements that have great quality, maximized absorption, and suitable dosage may work to benefit a lifetime of wellness!
