Best Apigenin Supplements for Stress, Sleep & Longevity

Apigenin is gaining attention as one of the most promising natural compounds for supporting sleep, stress reduction, and cellular health. Biohackers and longevity seekers alike are turning to this plant-based flavonoid to help optimize daily performance and promote healthy aging—without relying on pharmaceutical sleep aids.

In this guide, we’ll break down what apigenin is, why it works, and how to choose the best apigenin supplement based on clinical insight and real-world usage.

Our Top Picks for Apigenin Supplements

We’ve selected 6 of the best apigenin supplements on the market (to be added soon). Each one is ranked based on potency, purity, value for money, customer satisfaction, and added ingredients for synergistic benefits.

1. Best Overall Apigenin Supplement: aSquared Nutrition Apigenin 50mg + L-Theanine 200mg (120 Capsules)

• Why? Combines 50mg apigenin with 200mg L-theanine for synergistic sleep, stress, and cognitive support. Clean, vegan-friendly formula with third-party testing, made in the USA.
• Key Benefits: Supports deep sleep, promotes relaxation, enhances brain health, and provides antioxidant benefits.
• Best for: Individuals seeking a premium all-in-one nighttime formula for stress and sleep without melatonin.

2. Best Value Apigenin Supplement: Nutricost Apigenin 50mg (180 Capsules)

• Why? Delivers pure apigenin with no added fillers or blends. Vegan, gluten-free, and made in a GMP- and FDA-compliant facility. Long-lasting 6-month supply at a low cost per serving.
• Key Benefits: Supports sleep, hormonal balance, and mental clarity.
• Best for: Budget-conscious users looking for a clean, long-term supply of pure apigenin.

3. Best High-Potency Apigenin: Toniiq Ultra High Strength Apigenin 100mg (180 Capsules)

• Why? Offers 98%+ ultra-purified apigenin at 100mg per capsule, tested by third-party labs for purity and potency.
• Key Benefits: Enhances sleep, antioxidant defenses, NAD+ preservation, and hormonal balance.
• Best for: Biohackers and advanced users focused on purity, strength, and clinical-grade longevity support.

4. Best Budget-Friendly Apigenin: Deal Supplement Apigenin 100mg (240 Capsules)

• Why? Provides 100mg apigenin per serving at the lowest cost per dose. Sourced from chamomile, free from major allergens, and lab tested.
• Key Benefits: Promotes restful sleep, antioxidant support, and calmness.
• Best for: Beginners or long-term users wanting a naturally-sourced apigenin option at a great value.

5. Best Liposomal Apigenin for Absorption: Havasu Nutrition Apigenin 50mg (60 Capsules)

• Why? Features liposomal delivery for enhanced absorption, plus a clean, melatonin-free formula with cognitive and prostate health support.
• Key Benefits: Supports stress relief, brain health, and sleep without next-day grogginess.
• Best for: Users sensitive to melatonin or seeking a well-absorbed daytime or evening relaxation aid.

6. Best Chamomile-Free Apigenin: Force Factor Apigenin 50mg (60 Capsules)

• Why? Sourced from grapefruit instead of chamomile, ideal for sensitive users. Free from artificial flavors, dyes, and gelatin.
• Key Benefits: Calms the nervous system, aids in relaxation, and supports healthy aging.
• Best for: Individuals avoiding chamomile or looking for a clean-label, once-daily apigenin supplement.

Rank	Product	Form	Price per Count	Highlight	Key Benefits	Best For
1️⃣	aSquared Nutrition Apigenin 50mg + L-Theanine 200mg (120ct)	Capsule	$0.28	Best Overall Apigenin Supplement	Deep sleep, relaxation, cognitive clarity, antioxidant support	Those seeking a complete sleep formula with synergistic ingredients
2️⃣	Nutricost Apigenin 50mg (180ct)	Capsule	$0.11	Best Value Apigenin Supplement	Relaxation, sleep quality, mental clarity	Budget-conscious users building their own supplement stack
3️⃣	Toniiq Ultra High Strength Apigenin 100mg (180ct)	Capsule	$0.17	Best High-Potency Apigenin	Strong antioxidant effect, NAD+ support, neuroprotection	Biohackers and advanced users needing high-dose purity
4️⃣	Deal Supplement Apigenin 100mg (240ct)	Capsule	$0.09	Best Budget-Friendly Apigenin	Sleep support, stress relief, antioxidant activity	Beginners or long-term users wanting affordable apigenin
5️⃣	Havasu Nutrition Apigenin 50mg (60ct)	Capsule	$0.18	Best Liposomal Apigenin for Absorption	Sleep aid, mental focus, prostate health	Users wanting enhanced absorption without melatonin
6️⃣	Force Factor Apigenin 50mg (60ct)	Capsule	$0.18	Best Chamomile-Free Apigenin	Calmness, antioxidant support, healthy aging	Individuals avoiding chamomile or needing clean-label supplements

1. Best Overall Apigenin Supplement: aSquared Nutrition Apigenin 50mg + L-Theanine 200mg (120 Capsules)

Price: $34.95

aSquared Nutrition offers a high-strength apigenin supplement formulated with 50mg of apigenin and 200mg of L-theanine per capsule—designed to support sleep quality, relaxation, and mental clarity. With 120 capsules per bottle and only one capsule per day, this product delivers a 120-day supply, making it one of the most convenient and cost-effective options on the market.

Key Benefits

• Promotes deep, restful sleep without next-day drowsiness
• Supports relaxation and reduces nighttime anxiety
• May improve cognitive clarity and calm under stress
• Provides antioxidant and immune support
• Enhanced synergistically with L-theanine

What it Contains

• Apigenin – 50 mg per capsule
• L-Theanine – 200 mg per capsule
• Other ingredients: Methylcellulose Capsule, Microcrystalline Cellulose
• Form: Vegan capsules
• Serving size: 1 capsule per day
• Supply: 120 days

Pros

• High-potency formula with clinically relevant doses
• Includes calming L-theanine for synergistic effect
• Only 1 capsule per serving
• Third-party tested, made in GMP-certified facility
• Gluten-free, vegan-friendly, no preservatives
• Excellent value for a 4-month supply

Cons

• Not available in smaller trial-size bottle
• Some users may prefer a standalone apigenin option without L-theanine

Customer Feedback

• Sleep Quality: Many users report deeper and faster sleep onset, noting it feels “very relaxing” and “gently relaxes you” without next-morning grogginess. Some compared its effect to magnesium glycinate when paired together.
• Effectiveness: Most customers feel results within 20–30 minutes. Several highlight improved sleep quality, relaxation, and reduced anxiety after daily use.
• Ease of Use: With just one capsule per day, users appreciate the simplicity of the formula and its long-lasting supply.
• Strength: A few reviews mention better muscular endurance and overall wellness when taken regularly.

Best Suited For

• Adults seeking natural support for sleep and stress
• Biohackers and longevity-focused individuals
• People who want a non-habit-forming alternative to melatonin or sleep meds
• Those interested in synergistic blends like apigenin + L-theanine

Usage Recommendations

• Take 1 capsule (50mg Apigenin + 200mg L-Theanine) approximately 30–60 minutes before bedtime.
• Can be paired with magnesium glycinate or magnesium L-threonate for enhanced calming and sleep-promoting benefits.
• Safe for long-term use when taken as directed.

Summary: aSquared Nutrition delivers one of the most complete apigenin supplements on the market—combining clinical-strength 50mg apigenin with 200mg of L-theanine per capsule. Customers consistently report better sleep, reduced anxiety, and no grogginess. It’s a well-formulated, USA-made product that’s ideal for both nightly relaxation and long-term wellness.

2. Best Value Apigenin Supplement: Nutricost Apigenin 50mg (180 Capsules)

Price: $21.95

Nutricost delivers a straightforward and budget-friendly apigenin supplement with 50mg per capsule and a generous 180-day supply. This product is ideal for those who want a pure apigenin formula without additional ingredients. Made in a GMP-certified, FDA-registered facility and third-party tested, it offers impressive quality at a low per-serving cost.

Key Benefits

• Promotes relaxation and better sleep quality
• Simple, no-filler formula with clean ingredients
• Budget-friendly with long-term value
• May support hormone balance and cognitive clarity
• Vegan, gluten-free, and non-GMO

What it Contains

• Apigenin – 50 mg per capsule
• Other ingredients: Rice flour, hypromellose (cellulose) capsule
• Form: Vegan capsules
• Serving size: 1 capsule per day
• Supply: 180 capsules (6 months)

Pros

• Pure apigenin without unnecessary fillers
• Large 180-capsule bottle—excellent for long-term use
• Non-GMO, gluten-free, and vegan-friendly
• Manufactured in a GMP and FDA-compliant facility
• Low cost per serving ($0.11)

Cons

• No synergistic ingredients like L-theanine or magnesium
• Not tailored for stacking—best for experienced users who want to build their own combos

Customer Feedback

• Value for Money: Multiple reviewers call this product a “great value” and appreciate the high capsule count for the price.
• Effectiveness: Many customers report falling asleep faster and staying asleep longer, especially when combining it with magnesium glycinate, melatonin, or L-theanine.
• Ease of Use: The single-capsule dosage is convenient for nightly routines.
• Notable Mentions: One review warns of potential side effects when used for its aromatase-inhibiting effects, suggesting it’s best used at night to avoid daytime fatigue.

Best Suited For

• Budget-conscious users who want long-term supply
• Those seeking pure apigenin without added ingredients
• Sleep-focused users stacking it with their own magnesium or theanine
• People interested in apigenin’s anti-aging and neuroprotective properties

Usage Recommendations

• Take 1 capsule (50mg) about 30–60 minutes before bedtime.
• Consider combining with magnesium glycinate or L-theanine if relaxation or sleep support is your primary goal.
• For longevity or anti-aging purposes, consult with a practitioner for stacking guidance.

Summary: Nutricost Apigenin offers a simple, clean, and cost-effective way to supplement with 50mg of apigenin daily. With 180 capsules per bottle and no unnecessary extras, it’s ideal for stacking or long-term solo use—especially if you’re looking for maximum value without compromising on quality.

3. Best High-Potency Apigenin: Toniiq Ultra High Strength Apigenin 100mg (180 Capsules)

Price: $29.97

Toniiq delivers one of the most potent apigenin supplements available with 100mg per capsule and a rare 98%+ purity. This ultra-refined formula is designed for users who want maximum strength, especially for longevity, anti-inflammatory support, and deeper sleep. Each batch is rigorously tested both in-house and by independent labs.

Key Benefits

• Delivers high-dose apigenin at 100mg per capsule
• Supports deep sleep and relaxation
• May aid hormonal balance and NAD+ preservation
• Enhanced antioxidant and neuroprotective activity
• Ideal for high-bioavailability and clinical-grade stacking

What it Contains

• Apigenin – 100 mg per vegetarian capsule (98%+ purified)
• Other ingredients: Microcrystalline cellulose, vegetable capsule (HPMC), vegetable magnesium stearate, silicon dioxide
• Form: Vegan capsules
• Serving size: 1 capsule per day
• Supply: 180 days

Pros

• Among the highest dose and purity on the market (98%+)
• Independently tested for quality and potency
• No fillers, soy, or gluten
• Made in a USA-based GMP-certified facility
• Excellent choice for serious biohackers

Cons

• Higher cost per capsule compared to other options
• May be too strong for sensitive individuals or beginners
• No added calming ingredients like L-theanine

Customer Feedback

• Sleep Aid: Many users note improved sleep within 20–60 minutes of taking it. Reviews mention its fast onset and effectiveness for extreme insomnia.
• Quality: Toniiq is frequently praised for its product integrity, testing standards, and visible results. Users familiar with the brand report consistent performance.
• Strength: While most appreciate the potency, a few felt “off” or mildly agitated, possibly due to the high concentration or individual sensitivity.
• Effectiveness: Described as “expensive but worth every penny” by users who benefit from deeper, longer sleep or stack it for longevity benefits.

Best Suited For

• Experienced supplement users or biohackers
• Those seeking high-dose apigenin for NAD+ support or hormone modulation
• Individuals needing extra strength for stubborn sleep issues
• People focused on purity and clinical-grade quality

Usage Recommendations

• Take 1 capsule (100mg) with food, preferably in the evening to aid relaxation.
• Do not exceed the dosage without consulting a healthcare provider.
• Can be stacked with magnesium, quercetin, or theanine for added synergy, depending on your goals.

Summary: Toniiq Apigenin 100mg is one of the most refined and powerful apigenin supplements available—perfect for advanced users who value potency and purity. Backed by third-party testing and stellar user feedback, it’s a top-tier option for sleep, anti-aging, and stress support.

4. Best Budget-Friendly Apigenin: Deal Supplement Apigenin 100mg (240 Capsules)

Price: $23.99

Deal Supplement offers an incredibly affordable yet effective apigenin supplement sourced from chamomile flower extract, with 100mg per serving. This product provides 240 capsules per bottle, giving you a full 4-month supply—ideal for consistent, long-term use without breaking the bank. It’s lab-tested, non-GMO, gluten-free, and made in a cGMP-compliant facility.

Key Benefits

• Promotes restful sleep and calm
• Supports antioxidant activity and stress relief
• May aid muscle relaxation and nighttime recovery
• Sourced directly from chamomile with high apigenin yield
• Clean formula with no soy, gluten, or dairy

What it Contains

• Apigenin – 100 mg per serving (2 capsules = 50 mg each)
• Other ingredients: Silicon dioxide, magnesium stearate, rice flour, gelatin capsule
• Form: Capsules (non-vegan due to gelatin)
• Serving size: 2 capsules per day
• Supply: 120 servings (240 capsules total)

Pros

• Lowest cost per serving ($0.09)
• Natural chamomile source with preserved flavonoids
• Excellent for sleep and calmness, according to user feedback
• Non-GMO, gluten-free, and third-party tested
• Great value for beginners or long-term users

Cons

• Requires 2 capsules per serving to reach 100mg
• Not vegan (gelatin capsule)
• Purity level not specified (vs. 98%+ in premium options)

Customer Feedback

• Sleep Quality: Users widely praise this supplement’s ability to support deep, uninterrupted sleep. Some report “sleeping through the night” or better smart watch sleep scores after just a week.
• Effectiveness: Over 15 customers report it working consistently and effectively—especially after regular use over several weeks.
• Value for Money: This is a standout feature. Nearly all reviews highlight the “excellent product at a great price.”
• Calming Effect: Described as muscle relaxing, mildly sedating, and effective for stress, with benefits comparable to CBD-like calmness for some.

Best Suited For

• Budget-conscious users who want maximum capsule count
• Beginners starting apigenin for sleep or relaxation
• Those sensitive to additives—this formula avoids major allergens
• Anyone interested in a chamomile-based, naturally sourced extract

Usage Recommendations

• Take 2 capsules (100mg total) around 30 minutes before bedtime for best results.
• May be paired with other calming ingredients like magnesium, GABA, or L-theanine.
• Start with 1 capsule if you’re sensitive, then increase as needed.

Summary: Deal Supplement Apigenin delivers unbeatable value—100mg per serving, 240 capsules per bottle, and highly rated for sleep support and relaxation. While it lacks the ultra-high purity of premium brands, it’s a trusted and affordable choice backed by real user results.

5. Best Liposomal Apigenin for Absorption: Havasu Nutrition Apigenin 50mg (60 Capsules)

Price: $11.69

Nutricost Apigenin delivers 50mg of pure apigenin per capsule, sourced from a trusted U.S. brand known for clean formulations. This supplement is designed to support sleep, stress reduction, and overall wellness. It’s especially appealing to users who want a basic, effective, and cost-efficient apigenin option with a long supply.

Key Benefits

• Supports deeper, uninterrupted sleep
• Calms the mind before bedtime
• May enhance mood and reduce nighttime awakenings
• Can be stacked with magnesium, melatonin, and L-theanine for enhanced effect
• Offers 6-month supply in one bottle (180 servings)

Key Ingredients

• Apigenin (50mg per capsule)
• Capsule type: Vegan (hypromellose)
• Other ingredients: Rice flour, hypromellose (cellulose)

Pros

• Budget-friendly: ~$0.11 per capsule
• Vegan, gluten-free, and non-GMO
• 180 servings per bottle (excellent long-term value)
• 3rd-party tested for quality and purity
• Manufactured in a GMP-certified, FDA-registered facility

Cons

• Standard dose (50mg) may be too low for users seeking stronger sleep effects
• No additional ingredients to boost bioavailability
• Large bottle may be bulky for travel

Customer Feedback

• Value for Money:
  Customers praise it for its low cost per dose and long supply. Many said they use multiple Nutricost products due to affordability and quality.
• Effectiveness:
  Frequently used alongside magnesium, L-theanine, or melatonin to improve sleep. Users note falling asleep faster and staying asleep through the night.
• Ease of Use:
  Capsules are easy to swallow and fit well into nighttime supplement routines. Some users open the capsules and mix with drinks like cocoa.
• Side Effects:
  Minimal reported side effects. One user noted possible joint discomfort from long-term use due to apigenin’s aromatase-inhibiting properties.
• Overall Satisfaction:
  Most users are very happy with the results, especially when combined with other calming supplements. Sleep improvements were the most consistent benefit reported.

Highlighted Ingredients

• Apigenin: 50mg per capsule
• Other ingredients: Hypromellose (capsule), rice flour

Best Suited For

• Adults seeking a natural sleep aid
• Those stacking it with other nootropics or sleep supplements
• Budget-conscious users wanting a long-term supply

Usage Recommendations

Take 1 capsule 30–60 minutes before bed. For stronger effects, consider combining with magnesium glycinate or L-theanine.

Summary: Nutricost Apigenin is a budget-friendly and effective option for improving sleep quality and relaxation. Its clean formula and generous 180-capsule supply make it a top pick for long-term use, especially when stacked with other calming supplements.

6. Best Chamomile-Free Apigenin: Force Factor Apigenin 50mg (60 Capsules)

Price: $10.10

Force Factor’s Apigenin supplement offers 50mg per capsule sourced from grapefruit (Citrus paradisi), not chamomile—making it a unique option for those sensitive to chamomile-based formulas. With 60 vegan capsules per bottle, it’s designed to support relaxation and stress relief.

Key Benefits

• Promotes calmness and relaxation without grogginess
• Helps support healthy stress response and sleep
• Includes antioxidant support from apigenin
• Once-daily formula with no artificial dyes, sweeteners, or preservatives

Key Ingredients

• Apigenin (50 mg) per capsule, derived from grapefruit fruit powder
• Other ingredients: Hypromellose (veggie capsule), microcrystalline cellulose, magnesium stearate, silicon dioxide

Pros

• Vegan, non-GMO, no gelatin
• Free from artificial flavors, dyes, sweeteners, and preservatives
• Made in the USA in GMP-certified facilities
• Suitable for those avoiding chamomile

Cons

• Lower dose (50mg) compared to other brands with 100mg
• Some reviews mention inconsistent sleep support or no noticeable effect
• One user noted confusion over “prostate health” claim on label

Customer Feedback:

• Relaxation & Sleep Support:
  Many users say it helps them feel calmer and improves sleep. One customer wrote, “helps me sleep and no weird feelings.” Others noticed better deep sleep and use it as part of the Huberman sleep stack.
• Absorption Tips:
  One reviewer suggested opening the capsule and taking it under the tongue for better effect.
• No Side Effects:
  Several reviews reported no grogginess or side effects, which is ideal for sensitive users.
• Mixed Effectiveness:
  While some praised its effectiveness for stress and sleep, a few others said it didn’t noticeably help their sleep or needed combination with magnesium or theanine.
• Value for Money:
  Users felt it was a good value for the price and appreciated the clean ingredient profile.

Best Suited For

• Those looking for a chamomile-free apigenin source
• Users wanting stress or sleep support without melatonin
• People preferring a once-daily, clean-label supplement

Usage Recommendations

Take 1 capsule daily, preferably in the evening. Some users suggest combining it with magnesium and L-theanine for enhanced sleep effects.

Summary: Force Factor Apigenin is a clean-label, chamomile-free supplement that supports relaxation and sleep with minimal risk of side effects. It’s a smart choice for sensitive users or those following the Huberman sleep protocol.

What is Apigenin?

Apigenin is a naturally occurring flavonoid found in high amounts in chamomile, parsley, celery, and oranges. It has been used in traditional herbal medicine for centuries, primarily for its mild sedative, anti-inflammatory, and antioxidant effects.

Modern science now shows that apigenin:

• Modulates GABA-A receptors, which play a key role in calming the nervous system
• Inhibits CD38, an enzyme involved in aging and NAD+ depletion
• Reduces oxidative stress and inflammation, two major factors in chronic disease and cognitive decline

Potential Benefits of Apigenin Supplements

Research and anecdotal evidence suggest that apigenin supplementation may offer a wide range of health benefits:

• Supports Deep, Restful Sleep
  Apigenin interacts with the same calming receptors as some sleep medications—without the risk of dependency.
• Reduces Stress and Anxiety
  Acts as a natural relaxant, promoting a sense of calm without drowsiness when taken in lower doses.
• Promotes Healthy Aging
  By inhibiting CD38, apigenin may help preserve NAD+ levels—critical for cellular repair and longevity.
• Supports Brain Health
  May enhance memory formation, neurogenesis, and protect against age-related cognitive decline.
• Anti-Inflammatory & Antioxidant Effects
  Fights oxidative stress and supports immune balance, contributing to overall resilience.

How We Ranked the Best Apigenin Supplements

When choosing the best apigenin supplements, we considered:

• Apigenin dosage per serving (typically 25–50 mg)
• Purity and ingredient transparency
• Formulation quality (e.g., added chamomile, magnesium, luteolin for synergy)
• Customer reviews and brand reputation
• Third-party testing and certifications (e.g., non-GMO, vegan, gluten-free)

Who Should Take Apigenin?

Apigenin is a great choice for:

• Adults struggling with occasional insomnia or restless sleep
• People with high stress levels or anxiety
• Biohackers looking to boost NAD+ and optimize longevity
• Those interested in natural brain support or calming supplements
• Anyone seeking a non-habit-forming sleep aid

How to Use Apigenin Effectively

• Suggested Dose: Most people take 25–50 mg about 30–60 minutes before bed.
• Form: Found as standalone capsules or combined with calming nutrients like magnesium or chamomile.
• Stacking Options: Often paired with magnesium glycinate, l-theanine, or GABA for enhanced sleep quality.
• Cycling: While apigenin is generally safe for regular use, some users prefer to cycle it (e.g., 5 days on, 2 days off) for long-term effectiveness.

Possible Side Effects & Precautions

Apigenin is well tolerated by most users, but keep in mind:

• Mild drowsiness may occur—ideal for sleep but not for daytime use
• Avoid high doses if you are on blood thinners, as apigenin may have mild blood-thinning effects
• Pregnant or nursing women should consult a healthcare provider before use

FAQs About Apigenin Supplements

Final Verdict

Apigenin is a rising star in the world of natural health—offering promising benefits for better sleep, stress reduction, and longevity. Unlike prescription drugs, it works gently yet effectively, making it an ideal choice for anyone looking to optimize their body and mind through natural means.

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