Best 5 Calcium D-Glucarate Supplements for Detox and Hormone Balance (2025)

Looking to support your body’s natural detox system or balance hormones naturally? Calcium D-Glucarate is one of the most trusted supplements for aiding liver function and promoting healthy estrogen metabolism—two major health concerns for many adults today.

In this guide, we’ll explain what Calcium D-Glucarate is, how it works, who it’s best for, and what to look for in a quality supplement. Let’s start with our top product picks.

Our Top Picks for Calcium D-Glucarate Supplements

1. Best Absorption Support: Zazzee Calcium D-Glucarate 500mg + BioPerine + Broccoli Extract (100 Capsules)

• Why? Combines 500 mg Calcium D-Glucarate with 3 mg BioPerine and 100 mg Broccoli 10:1 Extract for enhanced hormone and detox support. Only product with BioPerine and broccoli extract together, improving absorption and adding phytonutrients.
• Key Benefits: Supports liver detox, hormone metabolism, antioxidant protection, and natural calcium intake (63 mg).
• Best for: Users seeking high-absorption CDG with synergistic botanicals and clean ingredients.

2. Best Value for Money: Nutricost Calcium D-Glucarate 500mg (120 Capsules)

• Why? Delivers a generous 120 capsules at a low cost per serving (~$0.14), with clean-label formulation: Non-GMO, gluten-free, vegetarian, and made in a GMP-certified facility.
• Key Benefits: Hormone balance, liver detox, cortisol regulation.
• Best for: Budget-conscious individuals looking for a simple, no-frills, high-quality CDG supplement.

3. Best Overall Calcium D-Glucarate: SMNutrition Calcium D-Glucarate 500mg + BioPerine (90 Capsules)

• Why? High customer satisfaction with 2,000+ ratings and multiple health benefits reported. Contains 500 mg CDG and BioPerine for absorption, plus clean, allergen-free formulation and third-party testing.
• Key Benefits: Supports estrogen metabolism, liver detox, hormonal balance, and bone health.
• Best for: Those seeking a premium, well-reviewed supplement with broad-spectrum hormonal support.

4. Best DIM + CDG Combo for Hormonal Balance: SMNutrition DIM + Calcium D-Glucarate 300mg/100mg (30 Capsules)

• Why? Combines two synergistic ingredients (DIM and CDG) with BioPerine to support estrogen detox and liver health. Well-suited for both women and men with estrogen imbalance.
• Key Benefits: Promotes estrogen clearance, liver detox, PMS relief, prostate and energy support.
• Best for: Men and women seeking a dual-action supplement for hormone and liver balance at a starter-friendly dose.

5. Best High-Dose CDG for Detox: NaturesPlus PRO Calcium D-Glucarate 600mg (90 Capsules)

• Why? Delivers the highest CDG dose (600 mg) with extended-release formulation. Vegan, non-GMO, and free from gluten/soy. Backed by detailed reviews highlighting detox, hormone balance, and high quality.
• Key Benefits: Phase II liver detox, hormone regulation, antioxidant support.
• Best for: Users needing a potent, long-acting CDG dose for intensive liver and hormonal detox support.

Rank	Product	Form	Price per Count	Highlight	Key Benefits	Best For
1️⃣	Zazzee Calcium D-Glucarate 500mg + BioPerine + Broccoli Extract (100ct)	Capsule	$0.25	Best Absorption Support	Enhanced detox, hormone support, antioxidant boost, natural calcium	Users seeking high-absorption CDG with synergistic botanicals
2️⃣	Nutricost Calcium D-Glucarate 500mg (120ct)	Capsule	$0.14	Best Value for Money	Hormone balance, liver detox, cortisol regulation	Budget-conscious individuals needing clean, potent CDG
3️⃣	SMNutrition Calcium D-Glucarate 500mg + BioPerine (90ct)	Capsule	$0.30	Best Overall Calcium D-Glucarate	Estrogen metabolism, liver detox, hormonal balance, bone health	Those seeking a premium CDG with broad-spectrum hormonal support
4️⃣	SMNutrition DIM + CDG 300mg/100mg (30ct)	Capsule	$0.30	Best DIM + CDG Combo for Hormonal Balance	Estrogen clearance, liver detox, PMS relief, prostate and energy support	Men and women needing dual-action hormone and liver balance
5️⃣	NaturesPlus PRO Calcium D-Glucarate 600mg (90ct)	Capsule	$0.31	Best High-Dose CDG for Detox	Liver detox, hormone regulation, antioxidant support	Users needing a potent, long-acting CDG detox supplement

1. Best Absorption Support: Zazzee Calcium D-Glucarate 500mg + BioPerine + Broccoli Extract (100 Capsules)

Price: $24.97

Zazzee’s Calcium D-Glucarate stands out for its high potency and enhanced absorption formula. Each capsule delivers 500 mg of Calcium D-Glucarate and is fortified with 3 mg of BioPerine® (black pepper extract) to boost bioavailability by up to 30%. It also includes 100 mg of broccoli 10:1 extract for added detox support. With 100 vegan capsules per bottle and clean-label manufacturing, it’s designed for both value and effectiveness.

Key Benefits

• Supports natural liver detox pathways
• Promotes healthy estrogen metabolism
• Enhances absorption with BioPerine®
• Offers all-natural calcium (63 mg per capsule)
• Supports antioxidant pathways with broccoli extract

Key Ingredients

• Calcium D-Glucarate – 500 mg
• BioPerine® (Black Pepper Extract) – 3 mg
• Broccoli 10:1 Extract – 100 mg
• Calcium (from Calcium D-Glucarate) – 63 mg
• Form: Vegan capsule
• Serving: 1 capsule daily

Pros

• Contains BioPerine® for improved absorption
• Includes broccoli extract for extra detoxification support
• High potency: only 1 capsule needed per serving
• 100% vegan, non-GMO, gluten-free, soy-free, and allergen-free
• Manufactured in the USA under GMP standards

Cons

• Slightly higher price per capsule compared to basic formulations ($0.25 per count)
• One review noted confusion between “dissolving” and “absorption” effects
• A few neutral reviews with no clear benefit reported

Customer Feedback:

• Value for Money:
  Many users appreciate the high capsule count and the inclusion of extra ingredients like BioPerine and broccoli extract, considering it a good value despite the premium price.
• Effectiveness:
  Users noted improvements in detoxification, breast health, and reduced estrogen-related symptoms. One reviewer highlighted it was recommended by a practitioner specifically for estrogen detox.
• Ease of Use:
  Most users find the capsules easy to swallow and convenient for daily use. One user even opened the capsules for animal rehab, indicating the powder dissolves well in food.
• Side Effects:
  No significant side effects were commonly reported. One reviewer questioned absorption clarity but did not report negative outcomes.
• Overall Satisfaction:
  The product holds a strong 4.4 out of 5-star rating from 50+ reviewers. Users generally trust Zazzee as a clean, effective brand.

Best Suited For
Those looking for a high-potency Calcium D-Glucarate formula with enhanced absorption and added detox support. Ideal for individuals focused on estrogen metabolism, liver health, and hormonal balance.

Usage Recommendations
Take 1 capsule daily with a meal to maximize absorption. Consider using consistently for at least 3–4 weeks to assess effectiveness. If you’re on hormone therapy or liver medications, consult your physician before use.

Summary: A high-absorption formula enhanced with BioPerine and broccoli extract, Zazzee Calcium D-Glucarate is ideal for users who want maximum detox and hormone balance support in just one capsule per day.

2. Best Value for Money: Nutricost Calcium D-Glucarate 500mg (120 Capsules)

Price: $18.95

Nutricost offers a simple yet highly effective Calcium D-Glucarate formula with an impressive 500 mg per capsule and a generous 120 capsules per bottle. With third-party testing, a clean label, and an affordable price point, this is one of the most budget-friendly yet high-quality options available. The product is vegetarian-friendly, non-GMO, and manufactured in a GMP-compliant, FDA-registered facility in the USA.

Key Benefits

• Promotes natural detoxification and liver health
• Supports hormone balance, especially estrogen metabolism
• May assist with cortisol clearance and better sleep
• Helps relieve menstrual cramps, according to some users
• Delivers 60 mg of all-natural calcium per capsule

Key Ingredients

• Calcium D-Glucarate – 500 mg
• Calcium (from Calcium D-Glucarate) – 60 mg
• Form: Vegetarian capsule
• Serving: 1 capsule daily

Pros

• Excellent price per capsule ($0.14/count)
• High potency in just one capsule
• No unnecessary fillers or additives
• Vegetarian, non-GMO, gluten-free
• Positive reputation with third-party testing

Cons

• Lacks absorption enhancers like BioPerine
• No added detox-supportive herbs (e.g., broccoli extract)
• Basic formulation may not be as comprehensive for some users

Customer Feedback:

• Value for Money:
  Widely appreciated for its affordability and generous supply. Many reviewers call it their “go-to” for a reliable and budget-friendly supplement.
• Effectiveness:
  Several customers mentioned relief from menstrual cramps, improved sleep, and better cortisol regulation—especially helpful for stress-related hormonal issues.
• Ease of Use:
  Only one capsule per day is needed, and users find it easy to swallow. Clean label adds to daily confidence in use.
• Side Effects:
  No significant side effects were noted. Users reported good tolerability even with long-term use.
• Overall Satisfaction:
  Rated 4.6 out of 5 stars by 280+ users. It’s an Amazon’s Choice product with consistently positive feedback for its quality and results.

Best Suited For
Anyone looking for a simple, high-quality Calcium D-Glucarate supplement that doesn’t break the bank. Ideal for long-term detox support or hormone-balancing regimens.

Usage Recommendations
Take 1 capsule daily with a meal. Consistent use over 2–4 weeks is generally needed to experience noticeable detox or hormonal benefits.

Summary: Nutricost Calcium D-Glucarate delivers potent detox and hormone support at one of the best values per serving—perfect for users who want clean ingredients and solid results without the extra cost.

3. Best Overall Calcium D-Glucarate: SMNutrition Calcium D-Glucarate 500mg + BioPerine (90 Capsules)

Price: $29.95

SMNutrition’s Calcium D-Glucarate offers a targeted approach to hormonal and liver health, especially for women dealing with estrogen dominance, menopause symptoms, or detox needs. Each capsule delivers 500 mg of Calcium D-Glucarate and 2.5 mg of BioPerine® for enhanced absorption. It’s vegan, non-GMO, third-party tested, and manufactured in a GMP-certified facility—making it a premium option with clean sourcing.

Key Benefits

• Helps regulate estrogen metabolism and reduce estrogen dominance
• Supports liver detox pathways for hormone and toxin clearance
• Assists in managing menopause-related symptoms (e.g., hot flashes, mood swings)
• Contains BioPerine® for increased absorption and effectiveness
• May support bone health and immune function as a secondary benefit

Key Ingredients

• Calcium D-Glucarate – 500 mg
• Calcium (from Calcium D-Glucarate) – 60 mg
• BioPerine® (Black Pepper Fruit Extract) – 2.5 mg
• Form: Vegan capsule
• Serving: 1 capsule per day

Pros

• Enhanced absorption with BioPerine®
• Excellent customer feedback for hormonal symptom relief
• Made without gluten, allergens, or artificial additives
• Backed by 3rd-party testing for purity and potency
• HALAL Certified and Non-GMO

Cons

• Slightly higher price per capsule ($0.30/count)
• No added herbal extracts like DIM or broccoli (must be taken separately)
• Limited to 90 capsules per bottle (3-month supply)

Customer Feedback:

• Value for Money:
  While it’s more premium-priced, many users find it worth the cost due to clear benefits and consistent results. “Affordable for what it offers” was a common theme.
• Effectiveness:
  Highly rated for estrogen balance, hot flash reduction, and PMS symptom relief. Some customers report clearer skin, better mood, and improved energy.
• Ease of Use:
  Capsules are reported as easy to swallow and gentle on digestion. Users consistently highlight the ease of daily use.
• Detox & Estrogen Support:
  Strong user feedback around improved liver health, reduced bloating, and even weight loss. “Game changer for hormone levels” and “menopause symptom relief” were standout comments.
• Overall Satisfaction:
  With over 2,200 reviews and a 4.6-star rating, this product is an Amazon’s Choice and praised for quality, consistency, and noticeable results.

Best Suited For
Women seeking natural hormone balance—particularly for perimenopause, PMS, or estrogen dominance. Also great for those combining DIM and CDG for synergistic hormone detox support.

Usage Recommendations
Take 1 capsule daily with a meal. Best paired with a DIM supplement for enhanced hormone balancing effects. Long-term use is recommended for sustained results, typically noticeable within 2–4 weeks.

Summary: SMNutrition’s Calcium D-Glucarate is a premium supplement focused on estrogen detox and hormonal balance. With BioPerine-enhanced absorption and strong customer-reported results, it’s ideal for women navigating hormone-related health changes.

4. Best DIM + CDG Combo for Hormonal Balance: SMNutrition DIM + Calcium D-Glucarate 300mg/100mg (30 Capsules)

Price: $9.95

This DIM + Calcium D-Glucarate combo by SMNutrition is ideal for those seeking a dual-action approach to estrogen balance and detox. Each capsule contains 100 mg of Diindolylmethane (DIM) and 300 mg of Calcium D-Glucarate (CDG), supported by 2.5 mg of BioPerine® for enhanced absorption. Though the CDG dose is lower than standalone products, its pairing with DIM makes it a favorite for both women and men experiencing hormonal imbalance, acne, or estrogen-related symptoms.

Key Benefits

• Combines two powerful hormone-regulating compounds: DIM and CDG
• Helps reduce estrogen dominance and supports estrogen metabolism
• Aids in clearing hormonal acne and improving skin clarity
• Supports liver detox pathways and hormonal balance in both sexes
• BioPerine® improves absorption and bioavailability

Key Ingredients

• Diindolylmethane (DIM) – 100 mg
• Calcium D-Glucarate – 300 mg
• BioPerine® (Black Pepper Extract) – 2.5 mg
• Form: Vegan capsule
• Serving: 1 capsule daily

Pros

• Two-in-one formula for convenience and synergy
• Great for PMS, menopause, acne, and prostate support
• Enhanced absorption with BioPerine®
• Non-GMO, third-party tested, and made in a cGMP-certified facility
• Excellent reviews for effectiveness and ease of use

Cons

• Only 30 capsules per bottle (1-month supply)
• Lower CDG dose (300 mg) than standalone products
• May not be suitable for those needing high-dose CDG alone

Customer Feedback:

• Value for Money:
  While each capsule is around $0.30, many users found the convenience of two powerful ingredients in one formula well worth the cost.
• Effectiveness:
  Highly rated for reducing heavy periods, improving energy, and regulating hormone levels. Users mention relief from estrogen dominance and even improved bone health.
• Ease of Use:
  Users appreciate the small capsule size and simplicity of taking one a day. Described as a reliable daily go-to.
• Estrogen Support & Functionality:
  Many reviewers say it helps them eliminate “bad estrogen” while preserving beneficial hormones. Others mentioned significant symptom improvement across mood, cycle regularity, and acne.
• Overall Satisfaction:
  With a 4.4-star average rating and many positive remarks, this formula is especially praised for balancing hormones and being easy to incorporate into daily routines.

Best Suited For
Anyone wanting a comprehensive solution for hormonal imbalance, especially those dealing with acne, PMS, menopause, or estrogen dominance. Men may also benefit from its potential for prostate and estrogen modulation support.

Usage Recommendations
Take 1 capsule daily with food. Consider combining with other hormone-supportive nutrients like magnesium or omega-3s for additional benefits. Best used consistently for 2–4 weeks to observe improvements in skin, mood, and hormone-related symptoms.

Summary: SMNutrition’s DIM + CDG supplement offers a smart, synergistic solution for estrogen detox and hormone balance. While lower in CDG dosage, it’s ideal for users looking to tackle hormonal acne, mood swings, and PMS with one effective daily capsule.

5. Best High-Dose CDG for Detox: NaturesPlus PRO Calcium D-Glucarate 600mg (90 Capsules)

Price: $27.95

NaturesPlus PRO offers a high-dose calcium D-glucarate supplement, delivering 600 mg per capsule. It’s vegan, non-GMO, gluten-free, and soy-free—targeted toward individuals seeking a clean-label detox aid. The product comes in a 90-capsule bottle (90 servings), made in the USA in a GMP-certified, FDA-registered facility.

Key Benefits

• Supports phase II liver detoxification and estrogen metabolism
• Promotes hormonal balance, especially helpful for estrogen-sensitive individuals
• May aid in antioxidant protection and cellular detox
• Designed for extended-release for prolonged effect

Key Ingredients

• Calcium D-Glucarate – 600 mg per capsule
• Calcium (from CDG) – 60 mg (5% DV)
• Other ingredients: vegetable cellulose, ascorbyl palmitate, silica, and microcrystalline cellulose

Pros

• Higher potency at 600 mg per capsule
• Extended-release formula for sustained activity
• Manufactured in the USA in a cGMP and NSF-registered facility
• Clean label: Vegan, non-GMO, gluten-free, soy-free
• Trusted brand with robust customer service and transparency

Cons

• Slightly more expensive per serving (~$0.31)
• Fewer total reviews compared to other brands (30 ratings as of now)
• No additional absorption boosters like BioPerine

Customer Feedback

• Value for Money: Most agree it’s a premium product, and though not the cheapest, its clean formulation and U.S. manufacturing justify the price.
• Effectiveness: Users praise its liver detox and estrogen-balancing effects, particularly for those with MTHFR gene variations or hormonal imbalance issues.
• Ease of Use: Reviewers report that capsules are easy to swallow and gentle on the stomach.
• Ingredient Quality: Verified buyers appreciate the high-quality ingredients and third-party testing.
• Overall Satisfaction: Many customers trust the brand and continue to reorder for detox and hormone support.

Highlighted Ingredients

• Calcium D-Glucarate – 600 mg
• Calcium – 60 mg
• Free from gluten, soy, and GMOs
• No added titanium dioxide or unnecessary fillers

Best Suited For

• Individuals needing strong liver detox support
• Those with estrogen dominance, MTHFR issues, or hormonal imbalance
• Active users seeking extended-release support for daily detox

Usage Recommendations

Take 1 capsule daily with a meal, or as directed by your healthcare professional. For best results, stay hydrated and pair with a clean diet for liver and hormonal health.

Summary: NaturesPlus PRO Calcium D-Glucarate delivers a powerful 600 mg dose in each vegan capsule, making it ideal for those who want maximum potency with clean ingredients. Though slightly pricier, it’s backed by quality standards and consistent detox and hormone balance support.

What is Calcium D-Glucarate?

Calcium D-Glucarate is the calcium salt of D-glucaric acid—a compound naturally found in fruits and vegetables like apples, oranges, broccoli, and Brussels sprouts. When taken as a supplement, it helps the liver remove excess hormones, toxins, and carcinogens from the body by supporting a process called glucuronidation.

This makes it especially valuable for those seeking hormone balance, liver detox support, or general wellness.

Key Benefits of Calcium D-Glucarate

• Supports Liver Detoxification
  Promotes glucuronidation, a key liver pathway for removing waste, hormones, and environmental toxins.
• Balances Estrogen Levels
  Helps prevent estrogen recirculation in the body, making it popular for women with estrogen dominance or men with hormonal imbalance.
• May Reduce Cancer Risk
  Preliminary studies suggest it may help reduce risks of hormone-related cancers like breast, prostate, and colon cancers.
• Aids Hormone-Related Weight Loss
  By optimizing estrogen levels and detox pathways, it may help address weight gain linked to hormone imbalance.
• General Antioxidant & Immune Support
  May help the body defend against cellular stress and improve overall metabolic function.

How to Choose the Right Calcium D-Glucarate Supplement

Not all supplements are created equal. Here are key things to consider:

• Dosage Per Serving
  Most effective products offer between 200 mg to 500 mg per capsule or serving. Therapeutic doses may go up to 1,000 mg daily.
• Formulation
  Capsule form is most common and convenient. Some products combine Calcium D-Glucarate with other ingredients like DIM, broccoli extract, or milk thistle for synergistic detox and hormonal benefits.
• Purity and Allergens
  Look for Non-GMO, gluten-free, soy-free, and vegan formulas. Avoid unnecessary fillers or binders.
• Third-Party Testing & Certification
  Quality brands will disclose independent lab testing to verify potency and purity.

Potential Side Effects and Safety

Calcium D-Glucarate is generally well-tolerated. However, some people may experience:

• Mild gastrointestinal discomfort (bloating or diarrhea)
• Lowered estrogen levels, which could be a concern for postmenopausal women or those on hormone therapy
• Drug interactions with medications affecting estrogen or liver metabolism

Always consult your doctor if you’re taking hormone replacement therapy (HRT), birth control pills, or other prescription medications.

FAQs about Calcium D-Glucarate Supplements

Final Verdict

Calcium D-Glucarate is a scientifically supported supplement that plays a vital role in liver detox and hormonal health. Whether you’re looking to reduce estrogen dominance, support weight loss, or protect against toxins, it’s a safe and effective option for both men and women.

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