Best 8 TMG Supplements

Trimethylglycine (TMG), also known as betaine, is gaining serious traction among health-conscious Americans for its impressive benefits in methylation, heart health, liver detox, and cellular function. Whether you’re dealing with high homocysteine levels or simply want to support your body’s natural detox and energy systems, TMG might be the missing link.

In this guide, we’ll cover what TMG is, why it matters, who needs it, and how to use it effectively—so you can make an informed choice when shopping for the best TMG supplement.

Our Top Picks for TMG Supplements

1. Best Overall TMG Supplement: Nutricost TMG 750mg (120 Capsules)

• Why? A well-balanced, affordable TMG formula with a moderate 750 mg dose per capsule, trusted by thousands of users. Manufactured in a GMP-certified facility and third-party tested.
• Key Benefits: Supports heart health, promotes healthy homocysteine levels, and aids methylation.
• Best for: Budget-conscious users looking for reliable, mid-range TMG dosing and consistent quality.

2. Best for Liver & Methylation Support: Force Factor TMG Betaine 1000mg (180 Capsules)

• Why? Offers 1000 mg per serving in a clean, vegan, non-GMO formula, specifically designed to support liver detoxification and methylation pathways.
• Key Benefits: Enhances liver health, supports detox, balances homocysteine, promotes methylation.
• Best for: Individuals focused on optimizing methylation and liver function, especially with clean-label preferences.

3. Best Powder Form: Nutricost TMG Powder 500g (3 Bottles)

• Why? Bulk powder offers flexibility in dosing and better value for long-term users. Each bottle provides 333 servings, ideal for stacking or large-scale use.
• Key Benefits: Supports methylation, liver function, cardiovascular health, and energy production.
• Best for: Experienced users or those looking to mix TMG into smoothies, shakes, or custom supplement regimens.

4. Best Liquid TMG: BBEEAAUU TMG Liquid Drops (1000mg per serving, 2 Fl Oz)

• Why? Fast-absorbing liquid format with added herbal adaptogens and vitamin B6. Ideal for quick energy and mood support with great absorption.
• Key Benefits: Boosts energy, supports methylation, enhances liver & cognitive health.
• Best for: Users who prefer fast-acting liquid supplements with a flavorful, easy-to-take format.

5. Best Tablet Format: Vitamatic TMG 1000mg (120 Tablets)

• Why? Delivers high-dose TMG in tablet form with a clean ingredient profile—free from major allergens and artificial additives.
• Key Benefits: Promotes cardiovascular health, supports methylation, regulates homocysteine.
• Best for: Users who prefer tablets over capsules and want a potent, no-frills option.

6. Best High-Dose & Budget Combo: Double Wood TMG 1000mg (180 Capsules)

• Why? Delivers excellent value with a high dose of 1000 mg per serving and 180 capsules per bottle. Third-party tested and widely trusted.
• Key Benefits: Supports cardiovascular health, reduces homocysteine, improves energy and athletic performance.
• Best for: Long-term users seeking high-potency and affordability from a reputable U.S. brand.

7. Best for Energy & Mood Boost: Life Extension TMG 500mg (60 Liquid Veg Capsules)

• Why? Clinically-backed brand offering a clean, vegetarian formula with easy-to-swallow softgels. Customers report enhanced mood and energy.
• Key Benefits: Promotes cardiovascular and liver health, supports mitochondrial energy, improves mood and well-being.
• Best for: Individuals who prefer softer capsules and value purity, energy, and mood benefits.

8. Best Premium Pick for Cellular Wellness: 10X Health TMG 1000mg (60 Capsules)

• Why? A premium supplement combining high-dose TMG with a focus on methylation, cellular health, and vitality. Higher cost, but praised for impact.
• Key Benefits: Supports heart health, energy, methylation, and liver function.
• Best for: High-performance users following biohacking or longevity protocols seeking a premium wellness boost.

Rank	Product	Form	Price per Count	Highlight	Key Benefits	Best For
1️⃣	Nutricost TMG 750mg (120 Capsules)	Capsule	$0.08	Best Overall TMG Supplement	Heart health, homocysteine support, methylation	Users needing balanced dose and value
2️⃣	Force Factor TMG Betaine 1000mg (180 Capsules)	Capsule	$0.10	Best for Liver & Methylation Support	Liver detox, methylation, homocysteine metabolism	Liver-focused users wanting clean formulation
3️⃣	Nutricost TMG Powder 500g (3 Bottles)	Powder	$0.79/oz	Best Powder Form	Custom dosing, long supply, cardiovascular support	Users preferring bulk powder for custom dosing
4️⃣	BBEEAAUU TMG Liquid Drops (2 Fl Oz)	Liquid	$14.00/fl oz	Best Liquid TMG	Energy, methylation, liver & brain support	Those who prefer flavored, fast-absorbing liquid
5️⃣	Vitamatic TMG 1000mg (120 Tablets)	Tablet	$0.08	Best Tablet Format	Cardiovascular health, homocysteine regulation	Tablet lovers wanting allergen-free formulation
6️⃣	Double Wood TMG 1000mg (180 Capsules)	Capsule	$0.06	Best High-Dose & Budget Combo	Homocysteine control, energy, cardiovascular health	High-dose seekers looking for great value
7️⃣	Life Extension TMG 500mg (60 Liquid Veg Capsules)	Liquid Veg Capsule	$0.15	Best for Energy & Mood Boost	Cardiovascular health, mood, energy	Users wanting softer capsules & mood boost
8️⃣	10X Health TMG 1000mg (60 Capsules)	Capsule	$0.32	Best Premium Pick for Cellular Wellness	Methylation, vitality, cellular health, heart support	Biohackers wanting high-end cellular support

1. Best Overall TMG Supplement: Nutricost TMG 750mg (120 Capsules)

Price: $9.95

Nutricost TMG provides 750mg of Trimethylglycine (Betaine Anhydrous) per capsule in a clean, gluten-free, and non-GMO formula. With 120 servings per bottle and a low cost of around $0.08 per capsule, it offers one of the best values in its category. Manufactured in a GMP-compliant, FDA-registered facility in the U.S. and third-party tested, it ensures consistent quality and safety. Many users report noticeable improvements in energy levels, stamina, post-exercise recovery, and mental focus. A common downside noted by reviewers is the naturally occurring fishy odor.

Benefits

• Enhances methylation and supports homocysteine metabolism
• Boosts energy and motivation throughout the day
• Improves physical endurance and reduces muscle soreness
• Supports detoxification and liver function
• May promote cardiovascular and brain health

What it Contains

• 750mg of TMG (Trimethylglycine) per capsule (betaine anhydrous)
• Other ingredients: gelatin capsule, magnesium stearate (vegetable source)
• Form: Capsule
• Count: 120 capsules
• Suggested use: 1 capsule daily

Pros

• High potency (750mg per capsule)
• Excellent price per serving
• Third-party tested, made in the USA
• Non-GMO and gluten-free
• Reported benefits for energy, focus, and recovery

Cons

• Strong fishy odor, which is typical of pure TMG
• Contains gelatin, not suitable for vegetarians or vegans

Customer Feedback:

• Value for Money: Customers say it’s a top-tier budget option, calling it “minimal cost for real results.”
• Effectiveness: Users report better workouts, clearer thinking, and noticeable stamina gains.
• Ease of Use: One capsule a day is convenient and easy to take.
• Pain Relief: Some report reduced soreness and better blood pressure control.
• Endurance & Energy: Frequently described as lasting longer than coffee without crashes.
• Smell: Most common complaint is a fishy smell, though many acknowledge it’s expected with pure betaine.

Best Suited For

This product is best suited for adults who want to support heart, liver, and brain health; individuals with elevated homocysteine levels or methylation issues (like MTHFR); athletes seeking better endurance and faster recovery; and budget-conscious users who still want a clean, effective formula.

Usage Recommendations

Take 1 capsule per day with or without food, preferably in the morning. For enhanced methylation support, pair with methylated B12 and folate. Avoid taking in the evening if you’re sensitive to stimulatory effects.

Summary: Nutricost TMG 750mg is a clean, cost-effective, and lab-tested supplement that delivers reliable support for methylation, cardiovascular health, and natural energy. While the fishy smell might be a turnoff for some, its performance and value make it one of the top TMG supplements available.

2. Best for Liver & Methylation Support: Force Factor TMG Betaine 1000mg (180 Capsules)

Price: $17.99

Force Factor delivers 1,000mg of Trimethylglycine (TMG) per serving using a clean, plant-based formula that’s free from gelatin, artificial dyes, sweeteners, and preservatives. With 180 capsules per bottle (90 servings), this supplement supports both liver health and methylation efficiency. It’s made in the USA and manufactured in GMP-certified facilities, ensuring quality and consistency. This product is well-suited for those prioritizing liver detox, cardiovascular wellness, and ingredient transparency.

Benefits

• Supports optimal methylation and healthy homocysteine levels
• Enhances liver detox pathways and overall liver health
• May boost energy and cellular function through improved methyl donor activity
• Clean-label ingredients with no artificial additives or sugars
• Suitable for strict plant-based and allergen-sensitive diets

What it Contains

• 1,000mg of Trimethylglycine (TMG) as betaine anhydrous per 2-capsule serving
• Other ingredients: hypromellose (capsule), microcrystalline cellulose, silicon dioxide, vegetable magnesium stearate
• Form: Capsule
• Count: 180 capsules (90 servings)
• Suggested use: 2 capsules daily

Pros

• High-potency formula at 1,000mg per serving
• Vegan, non-GMO, and free from gelatin, dyes, sweeteners, or preservatives
• Made in the USA in GMP-certified facilities
• Strong emphasis on liver and detox support
• Great fit for those avoiding animal-based capsules

Cons

• Requires 2 capsules per serving
• Slightly higher cost per dose compared to lower-dose products
• Limited customer reviews compared to more established TMG brands

Customer Feedback:

• Value for Money: Users appreciate the clean formula and high dose for the price, noting the quality is worth the cost.
• Effectiveness: Early reviews mention better digestion, improved energy, and feeling “cleaner” overall.
• Ease of Use: Capsule form is convenient and vegan-friendly, though some may prefer fewer capsules per dose.
• Smell/Taste: No common complaints reported about odor or aftertaste, a plus compared to fishier-smelling options.

Best Suited For

This supplement is best for individuals focused on liver detox and healthy homocysteine levels, especially those with methylation-related health concerns or who follow a vegan lifestyle. It’s also ideal for those who prefer clean-label formulas with no unnecessary additives or allergens.

Usage Recommendations

Take 2 vegetable capsules daily, preferably with food. For enhanced methylation support, this can be paired with active forms of B12 and folate. Because of its higher potency, some users may opt to split the dose into morning and afternoon for sustained effect.

Summary: Force Factor TMG 1,000mg offers a clean, vegan-friendly, high-potency TMG supplement designed for optimal liver support and methylation balance. With no gelatin or artificial ingredients, it’s an excellent pick for health-conscious users who want both purity and performance in their daily routine.

3. Best Powder Form: Nutricost TMG Powder 500g (3 Bottles)

Price: Price not available

Nutricost TMG Powder provides 500 grams of pure Betaine Anhydrous (TMG), with 1.5g per serving and a total of 333 servings per bottle. With zero artificial additives and just one inactive ingredient (calcium silicate), this unflavored powder is a clean option for those wanting higher doses or easy stackability. It’s manufactured in a GMP-compliant, FDA-registered facility and tested by ISO-accredited third-party labs to ensure quality. Users report great mixability, lasting energy, and enhanced workout performance, though taste opinions vary.

Benefits

• Supports healthy homocysteine metabolism and methylation pathways
• Enhances strength and performance when taken with pre/post-workout drinks
• May aid liver detoxification and reduce workout recovery time
• Great for stacking with NAD+ boosters, creatine, or amino acids
• Long shelf life and large quantity ideal for extended use

What it Contains

• 1.5g of Betaine Anhydrous (TMG) per scoop
• Other ingredients: calcium silicate
• Form: Powder
• Count: 500g per container (333 servings)
• Suggested use: 1 scoop daily, or as directed

Pros

• Massive supply with 333 servings per bottle
• Excellent mixability—blends easily with water or smoothies
• Pure formula with no preservatives, dyes, or flavors
• Flexible dosing—easy to tailor to workout needs or protocols
• Third-party tested and made in the USA

Cons

• Slightly bitter taste reported by some users
• Fishy odor noted by a few reviewers (common with betaine)
• Requires mixing, which may not suit users who prefer capsules

Customer Feedback:

• Value for Money: Users love the bulk value, calling it “a large supply for the money” and “enough to last a lifetime.”
• Effectiveness: Many report better workouts, improved NAD+ support, and noticeable physical results.
• Ease of Use: Dissolves easily in water or shakes, with users noting “better mixability than creatine.”
• Taste & Smell: Opinions vary—some report no taste, others mention a slight bitterness or mild fishy odor.
• Performance Benefits: Customers praise it for strength, energy, and fast recovery when used consistently with workouts.

Best Suited For

This product is best for experienced supplement users, athletes, and biohackers who prefer precise dosing, want to stack TMG with other performance-enhancing ingredients, or need long-term value. It’s also great for those following NAD+ protocols or seeking flexibility beyond standard capsule forms.

Usage Recommendations

Take 1 scoop (1.5g) per day mixed with water, juice, or a smoothie. It blends well in pre- or post-workout drinks and pairs effectively with creatine, NAD precursors, and B vitamins for enhanced results. For best absorption, avoid mixing with milk-based beverages.

Summary: Nutricost Betaine Anhydrous Powder is a high-value, clean, and highly mixable TMG option that supports liver detox, strength, and methylation. With 333 servings per bottle, it’s an unbeatable choice for athletes and supplement-savvy users looking for purity and performance.

4. Best Liquid TMG: BBEEAAUU TMG Liquid Drops (1000mg per serving, 2 Fl Oz)

Price: $25.99

BBEEAAUU TMG Liquid Drops deliver 1000mg of trimethylglycine (TMG) per serving in a flavorful blood orange formula. Unlike basic TMG products, this one also includes a potent blend of vitamins (B6, B12, folate, biotin) and herbal adaptogens like Rhodiola, Ginkgo, and Jiaogulan. Each bottle contains 15 servings (2ml per serving), and the formula is non-GMO, vegan, gluten-free, and alcohol-free. The liquid form is especially appreciated by users who want faster digestion and absorption compared to pills.

Benefits

• Supports homocysteine regulation and healthy methylation
• Helps boost energy, brain function, mood, and relaxation
• Promotes liver and kidney wellness
• May reduce fatigue and improve B-vitamin absorption in liquid form
• Enhanced antioxidant support from herbs like grape seed extract and red sage

What it Contains

• 1000mg Trimethylglycine (Betaine Anhydrous)
• 600mcg folate, 2.4mcg B12, 30mcg biotin, 1.3mg B6
• 50mg each of Ginkgo Biloba, Rhodiola Rosea, Jiaogulan, Panax Notoginseng, and others
• Other ingredients: maltitol syrup, purified water, natural flavor, citric acid, potassium sorbate
• Form: Liquid
• Count: 2 bottles, 1 fl oz (30ml) each (30 total servings)
• Suggested use: 2ml daily directly or mixed with water

Pros

• Convenient for those who dislike swallowing pills
• Fast-acting liquid absorption
• Enhanced with herbal adaptogens and B-complex nutrients
• Great-tasting citrus flavor
• Clean, vegan-friendly, gluten-free, and alcohol-free formula

Cons

• Small bottle with only 15 servings per unit
• Dropper design could be more accurate
• Slightly higher cost per serving compared to capsules or powders

Customer Feedback:

• Value for Money: Users say it’s a “great price for good quantity” and worth it for a liquid TMG with extras.
• Effectiveness: Customers feel more energized and say it helps with cognitive clarity and mood.
• Ease of Use: Many prefer it over pills due to convenience and faster effect.
• Taste: Most users enjoy the blood orange flavor, calling it “pleasant” or “sweet like tea.”
• Absorption: B vitamins and TMG in liquid form are described as more effective and gentle on the stomach.

Best Suited For

Best for adults who want fast-absorbing, well-rounded TMG supplementation that also supports stress, energy, and liver health. Especially suited for those who can’t swallow pills, or want added adaptogens and B-complex support in one formula.

Usage Recommendations

Take 2ml daily directly under the tongue or mix into water, juice, or smoothies. Best taken in the morning for energy support. Shake well before use and refrigerate after opening. Ideal when paired with other detox or energy protocols.

Summary: BBEEAAUU TMG Liquid Drops stand out for their fast-absorbing formula, delicious flavor, and added vitamins and herbs for liver, energy, and cognitive health. It’s a top choice for those wanting a complete, easy-to-take liquid methylation support solution.

5. Best Tablet Format: Vitamatic TMG 1000mg (120 Tablets)

Price: $9.99

Vitamatic TMG delivers 1000 mg of Trimethylglycine (TMG) per tablet, designed to support healthy homocysteine levels and overall cardiovascular health. It comes in tablet form with 120 servings per bottle and is made in a GMP-certified facility in the USA.

Key Benefits
• Supports healthy homocysteine metabolism
• Promotes cardiovascular wellness
• Offers antioxidant protection
• May assist in liver detox pathways

Key Ingredients
• Trimethylglycine (TMG) (Betaine Anhydrous) – 1000 mg per tablet
• Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, and more

Pros
• Affordable price per serving ($0.08)
• Non-GMO and gluten-free
• No artificial color, flavor, or preservatives
• Made in a GMP and FDA-registered facility

Cons
• Several users find the tablets large and hard to swallow
• Some tablets arrive partially crumbled
• No additional methylation co-factors like B vitamins

Customer Feedback
• Value for Money: Customers find this one of the best-value TMG supplements, with consistent praise for the price and size of the bottle.
• Product Quality: Many say it’s high quality and performs as expected.
• Pill Size: Mixed opinions. Some mention the tablets are very large and difficult to swallow, especially due to sharp edges.
• Ease of Use: Several users report having to break or crush the tablets, which may be inconvenient for daily use.

Best Suited For
• Budget-conscious buyers seeking basic TMG without added ingredients
• Adults looking to support heart and homocysteine health without complex formulations

Usage Recommendations
• Take 1 tablet daily, preferably with water and food.
• For those who find the size challenging, break the tablet in half or consider switching to capsules or powder forms.

Summary: Vitamatic TMG is a no-frills, budget-friendly choice for anyone looking for pure TMG at a great value. While the large pill size may be a drawback for some, the price and simplicity make it a solid option for homocysteine and heart support.

6. Best High-Dose & Budget Combo: Double Wood TMG 1000mg (180 Capsules)

Price: $9.95

Double Wood Supplements offers a well-known TMG (Trimethylglycine) formula designed to support healthy homocysteine levels, energy metabolism, and liver function. Each bottle provides 180 capsules—sufficient for up to 3 months at the standard dose. The supplement is manufactured in a GMP-certified, third-party tested facility in the USA.

Key Benefits

• Supports healthy homocysteine levels
• May promote better energy and endurance
• Aids liver detoxification and methylation
• Potential benefit for fat metabolism and blood pressure
• Cost-effective option for daily supplementation

Key Ingredients

• Trimethylglycine (TMG): 1,000 mg per serving (2 capsules)
• Other ingredients: Microcrystalline cellulose, gelatin capsule

Pros

• Third-party tested for purity
• Manufactured in the USA with globally sourced ingredients
• Large supply (180 capsules) at a very low cost
• Generally well-tolerated with effective energy and liver support
• No fillers or artificial additives

Cons

• Capsules reportedly have a strong fishy odor
• Several users reported half-filled or broken capsules
• Not vegan (contains gelatin)

Customer Feedback:

• Value for Money: Widely praised for being affordable and high-quality, with several noting it costs less than similar options or even health testing alternatives.
• Energy Level: Many users experience increased energy and better endurance, especially when used consistently.
• Effectiveness: Several customers noted visible results, including support for detoxification and improved absorption of other nutrients.
• Smell: A common downside—strong fishy smell mentioned by multiple reviewers, though some tolerate it as a sign of real TMG.
• Capacity Issues: Some users reported underfilled capsules or empty capsules, suggesting minor quality control problems.

Best Suited For

• Individuals looking to support cardiovascular health and methylation
• Fitness enthusiasts and those following anti-aging or detox protocols
• Budget-conscious consumers seeking a potent daily TMG dose

Usage Recommendations
Take 2 capsules (1,000 mg) daily, preferably with a meal. The brand suggests 1 to 3 servings per day depending on your health goals. Monitor smell and capsule condition upon delivery.

Summary: Double Wood TMG offers one of the best price-to-value ratios on the market with solid effectiveness for energy, liver function, and methylation. While the odor and occasional half-filled capsules may be off-putting to some, it remains a strong choice for those seeking affordable, genuine TMG supplementation.

7. Best for Energy & Mood Boost: Life Extension TMG 500mg (60 Liquid Veg Capsules)

Price: $9.75

Life Extension TMG 500 mg is a trimethylglycine (TMG) supplement in the form of liquid vegetarian capsules. Each serving delivers 1,000 mg of TMG (2 capsules), designed to support healthy homocysteine levels and promote cardiovascular, liver, and overall well-being. It’s non-GMO, gluten-free, and vegetarian-friendly, making it a clean option for daily use.

Key Benefits

• Promotes healthy homocysteine metabolism for cardiovascular health
• May help reduce inflammation and support liver detoxification
• Enhances mood and mental clarity
• Provides a noticeable energy boost and supports workout recovery
• Easy to swallow and gentle on the stomach

Key Ingredients

• Trimethylglycine (TMG) – 1000 mg per serving (as Betaine Anhydrous)
• Other ingredients: Glycerin, vegetable cellulose, purified water

Pros

• Backed by decades of research on TMG and heart health
• Vegetarian liquid capsules – easier to absorb and swallow
• Non-GMO and gluten-free
• Highly rated for quality and health benefits
• Strong user-reported outcomes on energy, mood, and liver support

Cons

• Some users reported nausea and stomach discomfort
• Leaky capsules were mentioned by a few reviewers
• Smaller bottle size (only 30 servings) compared to other options

Customer Feedback:

• Health Benefits: Customers consistently report improved cardiovascular function, reduced homocysteine levels, better energy, and overall wellness.
• Quality: The majority praise its premium quality and effectiveness, saying it fits well in their supplement regimen.
• Energy Boost: Users describe experiencing more energy, better mental clarity, and vitality, often within just a few days.
• Ease of Swallowing: The liquid vegetarian capsules are easy to take, with no strong taste or odor.
• Capsule Issues: A minority of users reported capsule leakage, especially when stored in pill containers.
• Side Effects: A few reviewers experienced nausea or stomach upset, especially when not taken with food.

Best Suited For
Ideal for adults seeking cardiovascular and liver support, particularly those focused on homocysteine control. It’s also a great option for individuals with MTHFR mutations or those seeking energy and mood support without synthetic additives.

Usage Recommendations
Take 2 capsules daily, preferably with meals. Users who experience nausea may want to split the dose or take it with a full meal to reduce discomfort.

Summary: Life Extension TMG 500 mg offers a research-backed, vegetarian formula to support heart, liver, and mental wellness. While some capsule quality concerns exist, its clean ingredients and high user satisfaction make it a solid choice for those prioritizing cardiovascular health.

8. Best Premium Pick for Cellular Wellness: 10X Health TMG 1000mg (60 Capsules)

Price: $20.50

10X Health TMG is a premium trimethylglycine supplement formulated to support homocysteine regulation, liver function, heart wellness, and energy production. Each bottle provides a 1-month supply with 60 capsules (30 servings), delivering 1000 mg of TMG per serving. This product targets those seeking methylation support and overall metabolic health.

Key Benefits

• Supports healthy homocysteine levels for cardiovascular protection
• Promotes liver detoxification and cellular methylation
• Enhances energy production and mitochondrial vitality
• Contributes to overall well-being and heart health
• Designed for daily support of genetic and metabolic functions

Key Ingredients

• Trimethylglycine (TMG) – 1000 mg per serving (from betaine anhydrous)
• Other ingredients: White rice flour, hypromellose (capsule), magnesium stearate, silicon dioxide

Capsule form, vegetarian-friendly, gluten-free, and non-GMO.

Pros

• High-dose TMG (1000 mg) for effective methylation support
• Clean formula with minimal fillers
• Good feedback on perceived improvements in heart health and energy
• Manufactured by 10X Health – a brand associated with performance-driven products

Cons

• Higher price per serving compared to other TMG supplements
• No certifications (like GMP or third-party testing) listed on the label
• Limited reviews compared to more established brands

Customer Feedback:

• Value for Money:
  Customers appreciate the value and efficacy, calling it a “great product” and “worth the cost,” despite its slightly higher price point.
• Effectiveness:
  Users report real-world benefits such as blood pressure control, overall vitality, and methylation support.
• Vitamin Value:
  Positive mentions of its role in regulating homocysteine, with some noting noticeable improvements in heart health.
• Feel Good Factor:
  Users felt better energy and well-being, describing changes as “outstanding” and “a definite improvement.”

Best Suited For

• Adults with elevated homocysteine levels or methylation issues
• Those seeking enhanced cardiovascular, liver, and mitochondrial health
• Users following DNA-based health or performance protocols

Usage Recommendations

Take 2 capsules per day with food, or as directed by your healthcare provider. Ideal in the morning to support daily methylation and energy cycles.

Summary: 10X Health TMG is a performance-focused supplement delivering 1000 mg of betaine anhydrous to support heart, liver, and energy metabolism. While priced higher than some competitors, users highlight strong results in cardiovascular health and vitality, making it a go-to option for those serious about methylation and well-being.

What is TMG (Trimethylglycine)?

TMG is a naturally occurring compound found in foods like beets, spinach, and quinoa. It acts as a methyl donor, helping the body convert homocysteine into methionine, a process crucial for DNA repair, detoxification, and cardiovascular health.

The body produces some TMG on its own, but many people—especially those with methylation issues or genetic variants like MTHFR—benefit from supplemental support.

Health Benefits of TMG

Here’s how TMG supplementation may improve your health:

• Supports Healthy Methylation: Essential for cellular repair, DNA synthesis, and neurotransmitter production.
• Reduces Homocysteine Levels: Elevated homocysteine is linked to heart disease and cognitive decline. TMG helps lower it naturally.
• Boosts Liver Function: TMG assists in fat metabolism and protects against fatty liver buildup.
• Enhances Energy & Mood: Some users report better stamina, focus, and emotional balance due to improved methylation.
• May Improve Physical Performance: TMG is used by athletes for endurance and recovery, although evidence is still emerging.

What to Look for in a TMG Supplement

Not all TMG supplements are created equal. Here’s what you should consider before buying:

• TMG Form & Dose: Most effective supplements contain anhydrous TMG at 500–1,000 mg per serving.
• Additions: Some formulas include B6, B12 (methylcobalamin), or folate (methylfolate) for synergistic methylation support.
• Capsule vs Powder: Capsules offer convenience, while powders are easier for dose adjustment and often more cost-effective.
• Clean Ingredients: Look for non-GMO, vegan, gluten-free, and third-party tested options. Avoid artificial additives or fillers.
• Reputation: Trusted brands with transparent labeling and quality control offer peace of mind.

Who Should Consider TMG?

TMG can benefit a wide range of individuals, particularly:

• Those with elevated homocysteine levels
• People with MTHFR or other methylation gene variants
• Individuals with fatty liver, sluggish detox, or high ALT/AST markers
• Athletes or bodybuilders looking for better endurance and recovery
• Anyone seeking brain support, mood balance, or improved energy

How to Take TMG for Best Results

• Recommended Dosage: 500–1,000 mg daily is typical. Some protocols use up to 3,000 mg under supervision.
• Timing: Morning or early afternoon is ideal. It can be taken with or without food.
• With B-Vitamins: Combining TMG with methylated B12 (methylcobalamin) and folate (5-MTHF) enhances its benefits.
• Duration: While some users notice benefits in a week, homocysteine reductions may take several weeks of consistent use.

Possible Side Effects

TMG is generally well-tolerated, but some users may experience:

• Mild digestive discomfort (especially at high doses)
• Restlessness or anxiety (especially if taken too late in the day)
• Not recommended for individuals with bipolar disorder without medical supervision, as it may increase manic symptoms

As always, consult your healthcare provider before starting TMG, especially if you’re pregnant, nursing, or taking medications.

Frequently Asked Questions

Final Verdict

TMG is more than just a supplement—it’s a key player in your body’s natural methylation cycle, impacting everything from cardiovascular health to liver detox and mental clarity. Whether you’re optimizing your longevity protocol or just looking for a natural way to support your wellness, TMG is worth considering.

Sharing is caring!