Top 5 Best Cissus Quadrangularis Supplements for Joint & Bone Support in 2025

Cissus Quadrangularis, a traditional herb long used in Ayurvedic medicine, is gaining attention in the U.S. for its impressive benefits on joint health, bone healing, and athletic recovery. Whether you’re dealing with chronic knee pain, recovering from an injury, or simply aiming to strengthen your musculoskeletal system, Cissus Quadrangularis may be a natural solution worth considering.

In this guide, we’ll walk you through everything you need to know about choosing the best Cissus Quadrangularis supplement for your health goals.

Our Top Picks for Cissus Quadrangularis Supplements

1. Best Overall Cissus Quadrangularis: Primaforce Cissus Quadrangularis 1000mg (120 Capsules)

• Why? Offers 1000 mg of pure Cissus extract per serving at a budget-friendly price, with no additives, preservatives, or fillers. Lab-tested for potency and manufactured with clean ingredients, making it a solid, no-nonsense choice.
• Key Benefits: Supports joint function, reduces inflammation, promotes tendon and ligament health.
• Best for: Individuals seeking a straightforward, effective, and affordable joint support supplement.

2. Best Value for High Potency: Nutricost Cissus Quadrangularis 1200mg (240 Capsules)

• Why? Offers a powerful 1200 mg dose per serving in a vegetarian-friendly capsule. With 240 capsules per bottle and 120 servings, it’s a great long-term option. Third-party tested and produced in a GMP-compliant facility.
• Key Benefits: Joint and tendon support, inflammation management, athletic recovery.
• Best for: Users needing a high-strength, long-lasting supply of Cissus at a competitive price.

3. Best for Tendon & Cartilage Health: Double Wood Cissus Quadrangularis 1000mg (150 Capsules)

• Why? Manufactured and tested in the USA with globally sourced ingredients, this supplement has strong customer feedback for tendonitis, joint pain, and cartilage repair. Non-GMO and gluten-free.
• Key Benefits: Supports collagen production, reduces tendon inflammation, enhances mobility.
• Best for: People experiencing joint wear, cartilage stress, or tendon injuries.

4. Best High Potency Ketosteroid Formula: Toniiq Cissus Quadrangularis 1200mg (120 Capsules)

• Why? Standardized to 40% ketosteroids, this formula delivers over 480 mg of active compounds per serving, making it one of the strongest extracts available. Wild-harvested and lab-tested in a GMP-certified facility.
• Key Benefits: Reduces joint pain, supports tissue regeneration, fights inflammation.
• Best for: Athletes or active users looking for maximum strength and standardized extract.

5. Best Ayurvedic Formula at Low Price: Jiva Botanicals Cissus Quadrangularis 1100mg (120 Capsules)

• Why? Uses a full-spectrum extract containing a broad range of plant compounds like flavonoids, resveratrol, and vitamin C. At just $0.13 per capsule, it provides excellent value for a natural Ayurvedic remedy.
• Key Benefits: Supports bone integrity, joint comfort, and muscle recovery.
• Best for: Budget-conscious users seeking traditional Ayurvedic support for joint health.

Rank	Product	Form	Price per Count	Highlight	Key Benefits	Best For
1️⃣	Primaforce Cissus Quadrangularis 1000mg (120ct)	Capsule	$0.11	Best Overall Cissus Quadrangularis	Joint support, inflammation relief, recovery boost	Affordable, clean joint support
2️⃣	Nutricost Cissus Quadrangularis 1200mg (240ct)	Capsule	$0.10	Best Value for High Potency	High-dose joint and tendon support, long-term supply	High-strength users needing large supply
3️⃣	Double Wood Cissus Quadrangularis 1000mg (150ct)	Capsule	$0.18	Best for Tendon & Cartilage Recovery	Collagen synthesis, flexibility, tendon pain relief	Tendon injuries, soft tissue stress
4️⃣	Toniiq Cissus Quadrangularis 1200mg (120ct)	Capsule	$0.21	Best High-Potency Ketosteroid Formula	Anti-inflammatory, cartilage regeneration, mobility	Athletes needing max-strength Cissus
5️⃣	Jiva Botanicals Cissus Quadrangularis 1100mg (120ct)	Capsule	$0.13	Best Ayurvedic Full-Spectrum Formula	Bone health, joint comfort, Ayurvedic herb blend	Budget users preferring traditional herbal support

1. Best Overall Cissus Quadrangularis: Primaforce Cissus Quadrangularis 1000mg (120 Capsules)

Price: $14.99

Primaforce Cissus Quadrangularis delivers a high-strength, standardized extract specifically designed for joint, bone, and connective tissue support. With 1,000 mg per serving and 40% ketosterones, this supplement is ideal for adults seeking fast-acting relief from joint discomfort or bone recovery.

Key Benefits

• Promotes joint comfort and reduces inflammation
• Supports tendon and ligament strength post-injury
• Aids bone healing and structural integrity
• May assist in reducing cortisol levels and enhancing recovery
• Highly bioavailable extract for fast results

Key Ingredients

• Cissus quadrangularis extract (root) – 1000 mg per serving, standardized to 40% total ketosterones
• Other ingredients: Gelatin capsule, corn starch, magnesium stearate (vegetable source), microcrystalline cellulose, silica

Form: Capsules
Serving size: 2 capsules
Servings per bottle: 60 (120 capsules total)

Pros

• High-potency extract (40% ketosterones)
• Lab-tested for purity and potency
• Non-GMO, gluten-free, no additives or preservatives
• Affordable at just $0.11 per capsule
• Trusted by over 500 customers per month on Amazon

Cons

• Contains gelatin (not vegan-friendly)
• No added complementary nutrients (e.g., collagen or turmeric)

Customer Feedback

• Value for Money: Customers widely appreciate its reasonable price and strong effectiveness. Many say it works as well or better than more expensive brands.
• Effectiveness: Several users experienced noticeable relief within 15–60 minutes of taking it. Some even avoided surgery due to improved joint mobility and reduced pain.
• Pain Relief: Users describe this as a “miracle herb” for joint pain, with lasting effects up to 24 hours after dosing.
• Ease of Use: Capsules are easy to take and conveniently dosed for once or twice-daily use.
• Quality: Consistently praised for clean formula and reliable packaging. Considered a solid alternative to USP Labs Cissus.

Best Suited For

• Athletes recovering from injury
• Individuals with joint pain or tendon issues
• Those seeking a high-dose, research-backed extract
• Budget-conscious users looking for purity and results

Usage Recommendations

Take 2 capsules daily, ideally with meals. For acute injury recovery or inflammation, some users split the dose morning and evening. Pairing with a balanced diet and adequate hydration may enhance results.

Summary: Primaforce Cissus offers a potent 1000 mg dose of 40% ketosterone-standardized extract in a clean, affordable capsule. With strong customer feedback on pain relief, value, and quality, this supplement is an excellent choice for joint and bone support, especially for active adults or those recovering from injuries.

2. Best Value for High Potency: Nutricost Cissus Quadrangularis 1200mg (240 Capsules)

Price: $26.95

Nutricost’s Cissus Quadrangularis offers a higher-potency formula with 1,200 mg per serving and 40% ketosterones derived from aerial parts of the plant. This supplement stands out with its vegetarian-friendly capsules, third-party testing, and large 240-capsule bottle — ideal for long-term users looking for consistent support in joint health and recovery.

Key Benefits

• Promotes joint comfort and mobility
• May assist in bone healing and regeneration
• Supports healthy inflammation response
• Contributes to better sleep and reduced stiffness
• Some users report appetite reduction and weight management benefits

Key Ingredients

• Cissus quadrangularis extract (aerial parts) – 1,200 mg per serving (2 capsules), standardized to 40% ketosterones
• Other ingredients: Hypromellose (vegetarian capsule), microcrystalline cellulose, magnesium stearate (vegetable source), silica

Form: Vegetarian Capsules
Serving Size: 2 capsules
Servings Per Container: 120 (240 capsules total)

Pros

• High dosage per serving (1,200 mg)
• Third-party tested for quality and potency
• Vegetarian-friendly and gluten-free
• Strong reputation on Amazon with Amazon’s Choice badge
• Excellent value: 120 servings for ~$24

Cons

• Slightly bulky bottle (for 240 capsules)
• A few comments mention unpleasant odor or taste

Customer Feedback

• Pain Relief: Users praise its ability to relieve bone and joint pain, with reports of improved energy and faster recovery for osteo-related issues.
• Effectiveness: Customers feel it helps with stiffness and soreness, and some mention improved sleep and joint mobility.
• Value for Money: Described as very affordable and “great quality for the price” compared to more expensive brands.
• Quality: Consumers are satisfied with the large quantity and consistent results, stating it’s equal or better than premium alternatives.
• Weight Loss: A few users noted reduced appetite and visible changes in body composition, especially when paired with a calorie-conscious diet.

Best Suited For

• Individuals needing a higher daily dose
• Vegetarians seeking a plant-based capsule
• Those on a budget looking for a large supply
• Users interested in joint, bone, and weight support

Usage Recommendations

Take 2 capsules daily, preferably with food. For enhanced joint support or inflammation management, pair with a healthy diet and consistent physical activity. Best stored in a cool, dry place to avoid capsule odor.

Summary: Nutricost Cissus Quadrangularis offers one of the most potent and budget-friendly options on the market. With 1,200 mg per serving, clean vegetarian capsules, and strong user feedback on joint relief and recovery, it’s a top choice for long-term supplementation and consistent results.

3. Best for Tendon & Cartilage Health: Double Wood Cissus Quadrangularis 1000mg (150 Capsules)

Price: $29.95

Double Wood’s Cissus Quadrangularis supplement provides a clean, USA-manufactured formula aimed at supporting cartilage, joints, and tendon health. Each serving delivers 1,000 mg of Cissus root extract, making it a solid choice for those looking to improve mobility, reduce inflammation, and enhance post-injury recovery. It’s third-party tested, non-GMO, and gluten-free.

Key Benefits

• May support collagen production for cartilage repair
• Eases joint pain and enhances flexibility
• Helps with range of motion and long-distance walking
• Reduces appetite and may assist with weight loss
• Promotes tendon and ligament resilience

Key Ingredients

• Cissus quadrangularis extract (root) – 1,000 mg per serving (2 capsules)
• Other ingredients: Hypromellose (vegetarian capsule), microcrystalline cellulose, vegetable stearate, silica

Form: Capsules
Serving Size: 2 capsules
Servings Per Container: 75 (150 capsules total)

Pros

• Manufactured in a GMP-certified, USA-based facility
• Non-GMO, gluten-free, and third-party tested
• Strong feedback for pain relief and motion improvement
• Also supports appetite suppression and muscle retention
• Balanced formula for both recovery and general wellness

Cons

• Slightly more expensive ($0.18 per capsule)
• Some users find the capsules taste strong or unpleasant
• Does not list ketosterone standardization

Customer Feedback

• Pain Relief: Over 270 users mentioned significant pain reduction, including recovery from fractures and tendonitis. Many report relief in knees, hips, and elbows.
• Effectiveness: Users consistently say it works better than glucosamine, with noticeable results within days.
• Value for Money: Despite being pricier, customers feel it’s a “cheap investment” compared to other joint treatments, citing high reliability.
• Quality: Rated as a “solid replacement” for premium products, with excellent purity and no reported side effects.
• Weight Loss & Appetite: Multiple users experienced reduced hunger, better dietary control, and visible fat loss, especially around the belly.
• Range of Motion: Reviews highlight improved joint fluidity and ease of movement, especially for those doing yoga or physical therapy.

Best Suited For

• Those recovering from injury (fractures, tendinitis, joint damage)
• Individuals needing all-around joint and tendon support
• Fitness enthusiasts wanting help with mobility and recovery
• People also seeking weight management and appetite control

Usage Recommendations

Take 2 capsules daily with food. Some users find it helpful to split the dose morning and evening. For best results, pair with gentle stretching, adequate hydration, and protein-rich meals to support collagen formation.

Summary: Double Wood Cissus Extract is a high-quality, USA-tested supplement trusted for pain relief, joint healing, and even weight support. Although slightly pricier, the overwhelming customer feedback and wide-ranging benefits make it a top choice for long-term recovery and wellness.

4. Best High Potency Ketosteroid Formula: Toniiq Cissus Quadrangularis 1200mg (120 Capsules)

Price: $24.97

Toniiq Cissus Quadrangularis offers an ultra-concentrated formula with a high standard of purity and potency. This supplement delivers 1,200 mg of cissus extract per serving, standardized to 40% ketosteroids, ideal for individuals seeking joint, tendon, and ligament support. It’s manufactured in a GMP-certified facility in the USA and third-party tested for quality and purity.

Key Benefits

• Supports joint and tendon health
• Promotes cartilage and bone recovery
• Reduces inflammation and joint pain
• Aids in weight management and appetite control
• Enhances mood and energy levels

Main Ingredients

• Cissus quadrangularis extract (aerial parts) – 1,200 mg per serving
• Standardized to 40% ketosteroids (approx. 480 mg per serving)
• Capsule type: Vegetarian
• Suggested use: 2 capsules daily

Notable Advantages

• Ultra-concentrated with one of the highest ketosteroid contents on the market
• Wild harvested in India
• GMP-certified, lab-tested, and third-party verified
• No fillers or additives; pure formulation

Potential Drawbacks

• Slightly higher price per capsule ($0.21)
• Some users noted delayed weight loss effects or minor insomnia

Customer Feedback:

• Pain Relief: Customers commonly noted a significant reduction in joint pain, especially in hips, knees, and shoulders. Many mentioned less reliance on painkillers and improved movement.
• Health Benefits: Users experienced joint recovery support, improved liver function, and better gym performance.
• Weight Loss: Several reported reduced appetite, waist fat loss, and enhanced body composition. A few noted results take time.
• Effectiveness: Positive feedback on fast-acting pain relief, potency, and comparison to traditional medications.
• Quality: Praised for purity, no fillers, and strong extract scent, indicating potency. Manufactured in a facility with good practices.
• Value for Money: Considered fairly priced for the high strength and effectiveness.
• Mood Enhancer: Some users felt improved energy, better focus, and reduced stress.
• Taste: Most noted it’s easy to swallow, with no aftertaste or odor.

Highlighted Ingredients

• Cissus Quadrangularis (aerial parts) – 1,200 mg
• Standardized to 40% Ketosteroids
• Capsule type: Vegetarian (Hydroxypropyl Methylcellulose)

Best Suited For

• Individuals with joint or tendon discomfort
• Athletes or active individuals in recovery
• People managing inflammation or seeking weight support
• Those looking for a high-purity, high-potency herbal product

Usage Recommendations
Take 2 capsules daily with water. For optimal results, consistent use over several weeks is advised. Best taken with meals or as advised by a healthcare professional.

Summary: Toniiq Cissus stands out for its high potency (40% ketosteroids), third-party testing, and clean formulation. It’s ideal for users seeking powerful joint support and consistent quality.

5. Best Ayurvedic Formula at Low Price: Jiva Botanicals Cissus Quadrangularis 1100mg (120 Capsules)

Price: Price not available

Jiva Botanicals offers a cost-effective Cissus Quadrangularis supplement designed to promote bone and joint health. Each bottle contains 120 capsules with a total daily serving of 1100 mg of Cissus extract. The formula features all-natural ingredients and is manufactured in the USA, making it a solid entry-level option for those seeking Ayurvedic joint support without a high price tag.

Key Benefits

• Promotes healthy bones and joints
• May aid in joint pain relief and stiffness reduction
• Can support muscle strength and recovery
• Gentle on the stomach with no reported side effects
• Vegan-friendly and free of additives

Key Ingredients

• Cissus Quadrangularis Extract (aerial part) – 1100 mg per 2-capsule serving
• Capsule Shell – Hypromellose (vegan)

Pros

• Budget-friendly at $0.13 per capsule
• Natural herbal formulation
• No reported side effects or unpleasant taste
• Manufactured in the USA

Cons

• Lower potency (no standardized ketosteroid content listed)
• Lacks third-party testing transparency
• Slower onset of effects for some users

Customer Feedback

• Value for Money: Many customers praise it as a “great vegan product” and a cost-effective choice for supporting aging joints.
• Effectiveness: Users report gradual relief from joint pain and increased mobility, especially in the knees, arms, and back. Some also note improvements in muscle definition and workout recovery.
• Ease of Use: Capsules are easy to swallow with no unpleasant aftertaste or stomach upset.
• Overall Satisfaction: Feedback is mostly positive, with reviewers appreciating the clean ingredients, natural formulation, and gentle effects. However, a few noted that results may take longer to become noticeable.

Best Suited For

• Budget-conscious individuals seeking joint support
• Vegans or those preferring plant-based capsules
• Beginners exploring Ayurvedic herbal supplements
• People with mild joint discomfort or early-stage joint stiffness

Usage Recommendations
Take 2 capsules daily, preferably with food. Consistent use over several weeks is recommended for optimal joint and bone health support.

Summary: Jiva Botanicals Cissus is a natural, affordable choice ideal for users new to joint support supplements. While it lacks high-standardized potency, it still provides noticeable benefits for mild to moderate joint issues and muscle recovery, especially when used consistently.

What is Cissus Quadrangularis?

Cissus Quadrangularis is a vine native to parts of Asia and Africa and has been used for centuries in Ayurvedic and traditional medicine. Known as “Veldt Grape” or “Hadjod,” this plant is best known for its ability to promote the healing of bones and connective tissue.

The key compounds in Cissus—like ketosterones, quercetin, and beta-sitosterol—are believed to support bone regeneration, reduce inflammation, and relieve joint discomfort.

Health Benefits of Cissus Quadrangularis

Here are some science-backed benefits of supplementing with Cissus Quadrangularis:

• Supports Bone Healing: Traditionally used to speed up fracture recovery and enhance bone regeneration.
• Promotes Joint Health: Helps reduce joint pain and inflammation, especially in active individuals or those with arthritis.
• Boosts Tendon and Ligament Strength: Useful for injury recovery and protecting soft tissues under physical stress.
• May Aid in Weight Management: Some studies suggest appetite-suppressing and metabolic-boosting properties.
• Rich in Antioxidants: Helps fight oxidative stress that contributes to joint degeneration.

How to Choose the Right Cissus Supplement

Not all Cissus supplements are created equal. Here’s what to look for:

• Standardized Extracts: Look for products standardized to 5–20% ketosterones for consistent potency.
• Clean Formula: Choose supplements free of fillers, GMOs, gluten, soy, or artificial additives.
• Form & Convenience: Capsules are the most convenient; powders offer dosing flexibility.
• Dosage Per Serving: Common doses range from 500 mg to 1,500 mg per day. Higher doses may offer faster relief but should be used with caution.
• Additional Ingredients: Some formulas include joint-supporting nutrients like collagen, boswellia, or MSM.

Potential Side Effects and Safety Tips

Cissus Quadrangularis is generally well-tolerated. However, some users have reported:

• Mild nausea or digestive discomfort
• Dry mouth
• Headaches in rare cases

To stay safe:

• Follow dosage instructions on the label.
• Talk to your doctor if you’re pregnant, nursing, or taking medications.
• Avoid combining with other strong anti-inflammatory herbs or NSAIDs unless supervised.

FAQs

Final Verdict

Cissus Quadrangularis is a powerful, plant-based supplement that supports bone and joint health, enhances recovery, and fits naturally into both athletic and aging wellness routines. Whether you’re an athlete, dealing with joint discomfort, or looking for a natural alternative to traditional pain relief, Cissus could be a smart addition to your supplement stack.

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