Best 6 Holy Basil Supplements for Stress Relief, Mood & Immunity 2025

Holy Basil, also known as Tulsi, has long been regarded as a sacred plant in Ayurvedic medicine. Known as the “Elixir of Life,” Holy Basil is a powerful adaptogen—an herb that helps your body manage stress more effectively. In recent years, it has gained popularity in the United States as a natural remedy to support immune health, reduce anxiety, regulate blood sugar, and promote overall wellness.

Whether you’re dealing with daily stress, immune challenges, or simply looking for a natural way to support vitality, Holy Basil supplements can be a gentle yet effective solution.

Our Top Picks for Holy Basil Supplements

1. Best Clinically Studied Holy Basil: Double Wood Tulsi Holy Basil (60 Capsules)

• Why? The only Holy Basil product in the lineup backed by a published clinical trial. Uses patented Holixer® extract standardized to 7 active compounds and shown to reduce stress and cortisol in 8 weeks.
• Key Benefits: Reduces cortisol, supports mood and relaxation, clinically validated.
• Best for: Users looking for evidence-backed results in stress reduction and emotional balance.

2. Best Ayurvedic Blend: Jiva Botanicals Holy Basil Capsules (90 Vegan Capsules)

• Why? Combines both Holy Basil extract and raw powder for a more holistic Ayurvedic profile. Rich in antioxidants and micronutrients like vitamin C, zinc, and iron.
• Key Benefits: Immune support, mood balance, antioxidant protection.
• Best for: Those wanting a traditional Ayurvedic formula with a nutritional boost.

3. Best Budget-Friendly Option: Nutricost Holy Basil 500mg (120 Vegetarian Capsules)

• Why? Offers a solid 500 mg dose per serving at just $0.10 per capsule. Made in a GMP-certified facility and free from gluten and GMOs.
• Key Benefits: Affordable stress support, antioxidant protection, and general wellness.
• Best for: Budget-conscious users seeking simple, effective Holy Basil without frills.

4. Best for Anxiety & Energy Support: MaryRuth Organics Holy Basil Liquid Extract (1 fl oz)

• Why? Sugar-free and alcohol-free liquid formula with 590 mg of organic Holy Basil per serving. Highly rated for anxiety relief, mood, and energy boost.
• Key Benefits: Promotes calm, supports digestion, aids in detox and energy.
• Best for: Those needing mood and anxiety support in a tasty, easy-to-use liquid form.

5. Best Liquid for Sleep & Mental Clarity: Global Healing Organic Tulsi (2 fl oz)

• Why? Uses bioavailable raw herbal extract technology with structured water and ormus minerals. Highly praised for promoting better sleep, calm, and daytime focus.
• Key Benefits: Stress relief, sleep support, immune boost, and clarity.
• Best for: Individuals seeking an advanced, holistic liquid formula for calm and clarity.

6. Best High-Potency Capsule: Zazzee Organic Holy Basil 10:1 Extract (120 Capsules)

• Why? Delivers 6000 mg strength per serving using a 10:1 extract, standardized to include Ursolic Acid. USDA Organic, non-GMO, and made with clean excipient-free ingredients.
• Key Benefits: Stress response, antioxidant support, adaptogenic resilience.
• Best for: Users needing a high-strength, organic formula with maximum capsule value.

Rank	Product	Form	Price per Count	Highlight	Key Benefits	Best For
1️⃣	Double Wood Tulsi Holy Basil (60ct)	Capsule	$0.17	Best Clinically Studied Holy Basil	Reduces cortisol, supports mood, clinically validated	Users wanting evidence-backed stress support
2️⃣	Jiva Botanicals Holy Basil (90ct)	Capsule	$0.22	Best Ayurvedic Blend	Immune support, mood balance, rich in micronutrients	Those seeking a traditional Ayurvedic formula
3️⃣	Nutricost Holy Basil 500mg (120ct)	Capsule	$0.10	Best Budget-Friendly Option	Affordable stress support, antioxidant protection	Budget-conscious users needing simple Holy Basil
4️⃣	MaryRuth Organics Holy Basil (1 fl oz)	Liquid	$17.95/fl oz	Best for Anxiety & Energy Support	Promotes calm, digestion, detox and energy	Users preferring easy-to-use liquid for anxiety
5️⃣	Global Healing Organic Tulsi (2 fl oz)	Liquid	$12.48/fl oz	Best Liquid for Sleep & Mental Clarity	Stress relief, immune boost, clarity and sleep	Users seeking holistic formula for calm and focus
6️⃣	Zazzee Organic Holy Basil 10:1 (120ct)	Capsule	$0.20	Best High-Potency Capsule	6000 mg strength, stress response, antioxidant	Users needing high-strength, organic extract

1. Best Clinically Studied Holy Basil: Double Wood Tulsi Holy Basil (60 Capsules)

Price: $9.95

Double Wood’s Holy Basil Holixer is one of the few supplements on the market backed by human clinical trials. Each capsule delivers 250 mg of a patented Holixer® extract, standardized to include a unique profile of 7 active compounds. Designed to support mood, stress resilience, and cortisol regulation, this product is ideal for anyone seeking scientifically grounded adaptogen support.

Key Benefits

• Clinically studied to reduce cortisol levels and perceived stress
• Promotes better sleep and calmness
• Supports adrenal health and mood regulation
• Contains a patented bioactive complex for consistent results
• Non-GMO, gluten-free, and third-party tested

Key Ingredients

• Holy Basil Extract (Holixer®) – 250 mg per capsule
  • Standardized to ≥ 5% Ocimum Bioactive Complex
  • Includes Rabdosin, Rosmarinic acid, Luteolin-7-o-beta-glucuronide, Ociglycoside I, and Apigenin-7-o-betaglucuronide
• Other ingredients: Hypromellose (capsule), Rice Flour, Microcrystalline Cellulose
• Suggested use: 1 capsule once or twice daily

Pros

• Clinically backed by an 8-week human study
• Targets stress, relaxation, and sleep quality
• Manufactured in the USA in a GMP-certified facility
• Patented standardization ensures potency and consistency
• Excellent value at just $0.17 per capsule

Cons

• Lower dosage per serving compared to some higher-potency formulas
• Not ideal for those seeking multi-herb adaptogen blends
• Some users reported no noticeable effects (individual response may vary)

Customer Feedback:

• Effectiveness for Sleep and Relaxation:
  Most users say the supplement “helps with sleep,” “relaxes you,” and “calms the mind.” Several mentioned it’s especially helpful for adrenal fatigue and fight-or-flight issues.
• Value for Money:
  Customers consistently praise its affordability and quality, especially considering it’s a clinically studied extract with patented ingredients.
• Ease of Use:
  The capsules are easy to take, with no strong taste or after-effects. Most users took 1 capsule before bed or in the evening for calming effects.
• Not for Everyone:
  While most reviews are positive, a few users didn’t feel much difference, indicating a variable personal response.

Best Suited For
Those looking for a research-backed Holy Basil supplement for stress, adrenal fatigue, and sleep improvement.

Usage Recommendations
Take 1 capsule once or twice daily, preferably with food. Some users find better results with evening use to aid sleep.

Summary: Double Wood’s Holy Basil Holixer stands out for its clinical backing, stress support, and affordability. It’s an excellent choice if you’re looking for a well-researched Holy Basil extract for stress, sleep, and adrenal health—without unnecessary fillers or blends.

2. Best Ayurvedic Blend: Jiva Botanicals Holy Basil Capsules (90 Vegan Capsules)

Price: $19.99

Jiva Botanicals offers a potent blend of organic Holy Basil leaf powder and extract in a vegan capsule. With 1100 mg per serving, this formula is designed to support immune health, stress response, and overall wellness through the traditional wisdom of Ayurveda. Made in the USA with non-GMO ingredients, it’s ideal for those seeking a natural and holistic adaptogen.

Key Benefits

• Delivers a powerful 1100 mg blend of Tulsi leaf powder and 2% ursolic acid extract
• Promotes immune strength and balanced stress response
• Rich in antioxidants, including vitamins C and A, zinc, and chlorophyll
• May help support mood stability and relaxation
• Plant-based and free from additives or preservatives

Key Ingredients

• Proprietary Blend – 1100 mg (per 2 capsules)
  • Organic Holy Basil
  • Holy Basil Extract (standardized to 2% ursolic acid)
• Other ingredients: Vegetable Capsule (Vegan)
• Suggested use: 2 capsules daily

Pros

• High-dose formula with both whole herb and standardized extract
• Vegan, non-GMO, and free from artificial fillers
• Affordable price for a 45-day supply
• Supports traditional Ayurvedic health goals
• Manufactured in the USA

Cons

• Proprietary blend does not disclose exact amounts of each component
• One user experienced headache and concerns about recent batch inconsistencies
• Some variability in capsule appearance noted in recent reviews

Customer Feedback:

• Effectiveness for Immunity and Calm:
  Users report noticeable benefits such as stronger immune response, stress reduction, and emotional balance. Some found it helpful for anxiety and toothaches.
• Value for Money:
  Customers appreciate the reasonable price for a high-dose herbal product, especially given the natural, organic formulation.
• Ease of Use:
  The vegan capsules are convenient, and most users take them daily without issue. However, some mentioned occasional headaches or capsule taste/smell variations.
• Mixed Experiences:
  While most reviews are positive, one user warned about potential changes in labeling, smell, and capsule color—raising concerns about batch consistency.

Best Suited For
Users seeking a strong herbal formula for anxiety, immunity, and detox support rooted in Ayurvedic tradition.

Usage Recommendations
Take 2 capsules daily. Consider starting with 1 capsule if sensitive to herbal products.

Summary: Jiva Botanicals Holy Basil offers a high-potency, organic herbal blend at a good price point. It’s a strong choice for those who value traditional Tulsi formulas for immunity, stress relief, and overall well-being—but it’s important to monitor for product consistency between batches.

3. Best Budget-Friendly Option: Nutricost Holy Basil 500mg (120 Vegetarian Capsules)

Price: $12.95

Nutricost offers a straightforward, high-value Holy Basil supplement that delivers 500 mg of extract standardized to 2.5% ursolic acid per capsule. With 120 servings per bottle and a price of just $0.10 per capsule, it’s a reliable option for budget-conscious users seeking daily stress support, antioxidant benefits, and mood balance.

Key Benefits

• Provides 500 mg of Holy Basil extract (Ocimum sanctum) per serving
• Standardized to 2.5% ursolic acid for anti-inflammatory and adaptogenic support
• May help reduce stress and anxiety while supporting immunity
• Offers antioxidant protection for cellular health
• Great value with a 4-month supply at a low cost

Key Ingredients

• Holy Basil Extract – 500 mg
  • Standardized to 2.5% ursolic acid
• Other ingredients: Hypromellose (cellulose) capsule, magnesium stearate (vegetable source), silica
• Suggested use: 1 capsule daily

Pros

• Excellent price-to-value ratio ($0.10 per serving)
• High-quality formula manufactured in a GMP and FDA-registered facility
• Non-GMO, gluten-free, and vegetarian capsules
• No reported side effects like grogginess or heartburn
• Simple, clean label—no proprietary blends

Cons

• Lacks additional synergistic adaptogens (e.g., Ashwagandha)
• Moderate dosage compared to higher-potency formulas
• Not clinically tested or standardized to as many active compounds as some premium options

Customer Feedback:

• Value for Money:
  Widely praised for being “worth the purchase” and “good price, decent product.” Several users mention this as the best price/quality option available.
• Effectiveness:
  Customers note calming effects, with benefits for anxiety relief, stress balance, and improved mood. Many appreciated that it works without making them feel groggy or tired.
• Quality:
  Users report consistent quality and satisfaction over time, calling it a reliable brand and a great basic supplement.
• Taste and Tolerance:
  Reviewers liked that the capsules have no funky taste, are easy to swallow, and cause no heartburn—a big plus for sensitive stomachs.

Best Suited For
Anyone looking for a reliable, affordable Holy Basil extract for daily mood and anxiety support.

Usage Recommendations
Take 1 capsule daily with food. Can be used in the morning or evening depending on your needs.

Summary: Nutricost Holy Basil 500mg is a no-frills, high-quality supplement at a very competitive price. It’s a top choice for budget-minded shoppers who want a dependable product for daily stress support and immune health.

4. Best for Anxiety & Energy Support: MaryRuth Organics Holy Basil Liquid Extract (1 fl oz)

Price: $19.95

MaryRuth’s Organic Holy Basil Leaf Liquid Extract is a USDA-certified organic herbal tincture that delivers a convenient and fast-absorbing alternative to capsules. With 590 mg per 0.5 mL serving, this product is designed to support stress reduction, mood balance, digestive comfort, and energy levels—all in a sweet-tasting, sugar-free formula.

Key Benefits

• Helps alleviate stress and promote emotional balance
• Supports anxiety relief and calmness without grogginess
• May improve digestion and energy levels
• Enhances focus and clarity throughout the day
• Great-tasting and easy to use

Key Ingredients

• Organic Holy Basil (Ocimum sanctum) Leaf Extract – 590 mg per 0.5 mL
• Other Ingredients: Organic vegetable glycerin, purified water
• Form: Liquid drops (1 fl oz / ~60 servings)

Pros

• USDA Organic, sugar-free, vegan, and non-GMO
• Excellent for people who dislike swallowing pills
• Sweet taste with no unpleasant aftertaste
• Fast onset of effects, based on user reviews
• Multi-targeted benefits: anxiety, focus, digestion, sleep

Cons

• Bottle may run out quickly with frequent use
• Slightly more expensive per dose compared to capsules
• Some users may prefer precise capsule dosing

Customer Feedback:

• Anxiety Relief:
  Users frequently report calmer nerves, improved stress response, and better sleep quality. Many consider it a staple for managing daily anxiety and emotional overwhelm.
• Taste:
  Most describe the flavor as pleasant, sweet, and herbal. No complaints of bitterness or aftertaste. Several noted that the taste encouraged regular use.
• Quality:
  Customers consistently praise the high quality and purity, often noting many health benefits beyond stress relief—especially for digestion and energy.
• Ease of Use:
  Reviewers find the liquid format easy to administer, either directly or mixed in drinks like tea or smoothies. It’s also a popular choice for on-the-go use.
• Effectiveness:
  Multiple users mention they feel the calming effects within minutes to a few doses, making it a fast-acting solution compared to some capsule options.

Best Suited For
Ideal for adults seeking a gentle, organic, and fast-acting liquid adaptogen for managing anxiety, improving focus, and promoting calm without capsules.

Usage Recommendations
Take 0.5 mL (approx. 15 drops) 1–2 times daily. Can be taken directly or diluted in water, tea, or a smoothie. Best taken consistently to support mood and energy.

Summary: MaryRuth’s Organic Holy Basil Drops are a top-rated, fast-acting, and delicious liquid option for those seeking daily stress and anxiety relief with added digestive and focus benefits—perfect for people avoiding capsules.

5. Best Liquid for Sleep & Mental Clarity: Global Healing Organic Tulsi (2 fl oz)

Price: $24.95

Global Healing Center’s Organic Tulsi (Holy Basil) Raw Herbal Extract delivers 1 ml of organic tulsi per serving in a concentrated, bioavailable liquid form. With 60 servings per bottle, this USDA Organic, non-GMO, gluten-free formula is designed to promote relaxation, improve sleep, and support immune and mental wellness.

Key Benefits

• Promotes a calm nervous system and better mood balance
• Supports deeper sleep quality, especially for stress-related issues
• May aid in immune support and lung health
• Helps manage daily stress and anxiety attacks
• Encourages natural energy and enhanced mental clarity

Key Ingredients

• Organic Tulsi Leaf Extract (Ocimum sanctum) – 1 ml per serving
• Other ingredients: Organic vegetable glycerin, biophotonic structured water, ormus minerals

Pros

• USDA Organic, non-GMO, and gluten-free
• Contains structured water and trace minerals for enhanced absorption
• Strong user feedback for stress relief and sleep aid
• No artificial fillers or preservatives
• Convenient dropper form for fast action and easy dosing

Cons

• Taste is divisive — some users report it’s too pungent or earthy
• Pricier than some other holy basil products at $24.95 per bottle
• Some users felt the bottle empties quickly, especially with regular use

Customer Feedback

• Quality: Most users rated it highly for consistent results and overall quality, calling it a “great product” that works well with daily use.
• Calming Effect: Highly praised for easing anxiety, relaxing the body, and promoting peaceful sleep — often within 30 minutes of use.
• Sleep Support: Many users take it at night and report deeper, uninterrupted sleep. Also noted to help with perimenopausal insomnia.
• Health Benefits: Users mentioned immune boosts, clearer skin, and improved lung health.
• Taste: Opinions vary — some enjoy its slightly sweet, earthy taste, while others find it overly strong or unpleasant.
• Value for Money: Mixed reviews — some call it worth the price, while others found it expensive or disliked recent changes in taste or consistency.

Best Suited For

• Individuals seeking a natural alternative for anxiety relief or better sleep
• Those dealing with daily stress or burnout
• Users interested in Ayurvedic support and detox benefits

Usage Recommendations
Shake well before use. Take 1 ml twice daily, or as advised by your healthcare provider. Can be taken directly or added to water/tea for milder taste.

Summary: Global Healing Center’s Organic Tulsi is a potent liquid extract designed for those who want immediate support for sleep, anxiety, and immune health. Its organic, bioavailable formula is praised for calming the mind and body — just be aware the taste may not suit everyone.

6. Best High-Potency Capsule: Zazzee Organic Holy Basil 10:1 Extract (120 Capsules)

Price: $23.97

Zazzee Organic Holy Basil is a high-potency supplement that delivers 6000 mg strength per serving using a concentrated 10:1 Tulsi extract. Each bottle includes 120 vegan capsules, making it a value-packed option for those seeking stress and immune support in capsule form. It’s USDA Certified Organic, vegan, and non-GMO.

Key Benefits

• Promotes calmness and reduces stress levels
• Supports immune function and antioxidant activity
• Aids mental clarity and sleep quality
• Contains Ursolic Acid for added adaptogenic benefits
• Easy-to-take vegan capsules with no artificial ingredients

Key Ingredients

• Organic Holy Basil 10:1 Extract – 600 mg (equivalent to 6000 mg of raw herb)
• Standardized to contain naturally occurring Ursolic Acid
• Other ingredients: Organic pullulan capsule, organic rice powder and extract

Pros

• Extra strength 10:1 extract for higher potency
• Contains Ursolic Acid (key bioactive compound)
• USDA Certified Organic and 3rd-party lab tested
• No artificial ingredients or common allergens
• Excellent price-per-serving ratio

Cons

• May cause mild next-day tiredness in some users
• Calming effects could be too subtle for those needing fast results
• Some reviews mention limited support for severe insomnia

Customer Feedback:

• Calming Effect: Most users feel calmer and less anxious, with many saying it helps with sleep. A few noted drowsiness the next day.
• Quality: Customers rate the product highly for purity, potency, and overall value.
• Effectiveness: Many users report it works well for stress management and emotional balance, especially when taken consistently.

Best Suited For
Those seeking a high-dose, capsule-based holy basil supplement to support stress relief, immune health, and daily emotional balance. Ideal for users who want USDA-certified organic capsules with high extract concentration.

Usage Recommendations
Take 2 capsules daily with food or as directed by a healthcare provider. Consistent use may enhance effects, particularly for managing chronic stress and mood.

Summary: Zazzee Organic Holy Basil stands out for its extra-strength 6000 mg equivalent dose, USDA certification, and naturally occurring Ursolic Acid. It’s a top pick for those looking for a high-quality, capsule-based adaptogen at a great value.

Benefits of Holy Basil Supplements

Holy Basil is more than just a traditional remedy—it’s backed by growing scientific research. Here are the main benefits associated with this herbal powerhouse:

• Stress Reduction: Holy Basil helps regulate cortisol, your body’s primary stress hormone, making it a natural choice for anxiety and burnout.
• Immune Support: Rich in antioxidants and antimicrobial compounds, Tulsi supports a strong and responsive immune system.
• Inflammation Control: Its anti-inflammatory properties may help reduce symptoms linked to chronic inflammation, such as joint pain and fatigue.
• Blood Sugar Balance: Studies suggest that Holy Basil may help stabilize blood sugar levels, making it useful for those with metabolic concerns.
• Mood and Cognitive Boost: Some users report better focus, less brain fog, and improved mood after regular use.

How We Chose the Best Holy Basil Supplements

Not all supplements are created equal. Here’s what we look for in a high-quality Holy Basil supplement:

• Standardized Extracts: Products that provide a guaranteed amount of active compounds like ursolic acid or eugenol.
• Clean Label: Free from unnecessary fillers, artificial additives, or allergens.
• Third-Party Testing: Ensures purity, potency, and absence of contaminants like heavy metals.
• Bioavailability: Some formulas include black pepper extract (piperine) to enhance absorption.
• Value per Serving: We evaluate cost-effectiveness based on dose and number of servings.

Key Ingredients to Look For in Holy Basil Supplements

Most Holy Basil supplements contain one or more of the following:

• Holy Basil Leaf Extract: Often standardized to contain 2% or more of ursolic acid or eugenol, both believed to offer stress-reducing and immune-boosting benefits.
• Whole Herb Powder: Offers a more traditional form of the plant but may be less concentrated.
• Synergistic Blends: Some supplements combine Holy Basil with other adaptogens like Ashwagandha, Rhodiola, or Lemon Balm for added stress relief.

Common Dosage:

• Capsule form: 300–600 mg per serving, usually once or twice daily
• Liquid extract: 30–60 drops in water or juice, 1–2 times daily

Who Should Take Holy Basil Supplements?

Holy Basil may be especially beneficial for:

• Individuals experiencing chronic stress, burnout, or anxiety
• Those with weakened immunity or frequent colds
• Adults looking to improve mental clarity and emotional resilience
• People managing blood sugar or inflammatory issues
• Health-conscious individuals seeking natural wellness solutions

While generally safe, pregnant or breastfeeding women should consult a healthcare provider before using Holy Basil.

How to Use Holy Basil Supplements

To get the most from your Holy Basil supplement:

• Timing: Take with meals to enhance absorption and reduce the chance of stomach upset.
• Consistency: For adaptogenic herbs like Tulsi, regular use is key—most benefits appear after 2 to 4 weeks.
• Combination: Consider pairing it with other stress-support supplements like magnesium or L-theanine for a synergistic effect.

FAQs

Final Verdict

Holy Basil is one of the most effective and time-tested herbs for supporting stress resilience, immune health, and mental clarity. Whether you’re battling daily stress, looking for a gentle way to support blood sugar balance, or just want to feel more energized and clear-headed, Holy Basil is worth considering.

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