Looking for a natural way to support your heart and blood circulation? Nattokinase might be the supplement you’ve been missing. This enzyme, derived from traditional Japanese natto, has gained increasing attention in the U.S. for its ability to help maintain cardiovascular health, support healthy blood pressure, and promote optimal circulation.
In this article, we’ll explore the key benefits of nattokinase, how to choose the right supplement, and address common questions to help you make an informed decision.
Our Top Picks for Nattokinase Supplements
1. Best Overall Nattokinase: Nutricost Nattokinase 2,000FU (120 Capsules)
- Why? Delivers a clinically supported 2000 FU dose per capsule in a clean, gluten-free, vegetarian-friendly formula. Highly rated, 3rd-party tested, and one of the most cost-effective nattokinase options available.
- Key Benefits: Supports cardiovascular health, healthy blood circulation, and natural fibrinolysis.
- Best for: Users looking for a pure, well-tested nattokinase supplement at an affordable price for long-term use.
2. Best High-Volume Supply: Zenavea Nattokinase 2000 FU (270 Capsules)
- Why? Offers a massive 9-month supply with 270 vegan capsules, each containing 2000 FU. Clean label and manufactured in the USA under strict GMP standards.
- Key Benefits: Enhances blood flow, supports heart and circulatory health, and helps prevent clotting.
- Best for: Budget-conscious users seeking a high-quantity, long-term cardiovascular supplement.
3. Best Multi-Enzyme Complex: Clean Nutraceuticals Nattokinase 4000 FU with Serrapeptase, Lumbrokinase & Co-Factors (60 Capsules)
- Why? Combines 4000 FU of nattokinase with other potent enzymes (serrapeptase, lumbrokinase) and antioxidants like rutin, CoQ10, turmeric, and vitamin C for comprehensive heart, immune, and inflammatory support.
- Key Benefits: Broad-spectrum support for circulation, inflammation, cardiovascular and immune health.
- Best for: Individuals looking for an all-in-one advanced enzyme complex for systemic wellness.
4. Best Vegan-Friendly Formula: Force Factor Nattokinase 2000 FU (90 Vegetable Capsules)
- Why? Non-GMO, vegan, and free from gelatin and artificial additives. Made in the USA in GMP-certified facilities, providing trustworthy quality at a budget-friendly price.
- Key Benefits: Promotes smooth blood flow, supports cardiovascular function, and helps maintain healthy blood pressure.
- Best for: Plant-based users who want a clean, heart-healthy supplement without breaking the bank.
5. Best for Enzyme Synergy: VINATURA Lumbrokinase, Nattokinase 2000FU & Serrapeptase (60 Capsules)
- Why? A uniquely balanced formula combining nattokinase, 800,000 units of lumbrokinase, and 125,000 SPU serrapeptase—plus beetroot and rutin—for circulation, clot control, and inflammation.
- Key Benefits: Supports blood flow, vascular integrity, and enzyme-driven detox.
- Best for: Users seeking a well-rounded blend of powerful enzymes with scientific dosing.
6. Best Delayed-Release Formula: Bio Absorb Nattokinase 2000 FU (60 Veggie Capsules)
- Why? Uses DRcaps for delayed release, ensuring enzyme activity is preserved through digestion. Non-GMO and allergen-free, manufactured in Canada in GMP-certified facilities.
- Key Benefits: Promotes healthy circulation and cardiovascular support without vitamin K2.
- Best for: Sensitive individuals or those concerned with absorption and ingredient purity.
7. Best with Omega-3s: New Elements Nattokinase 4000 FU with Antarctic Krill Oil (60 Softgels)
- Why? Combines 4000 FU of nattokinase with 2000 mg of krill oil rich in DHA and EPA, targeting both circulation and inflammation in one softgel.
- Key Benefits: Improves heart health, blood flow, brain function, and joint support.
- Best for: Those seeking dual-action cardiovascular and omega-3 support in one easy-to-swallow softgel.
| Rank | Product | Form | Price per Count | Highlight | Key Benefits | Best For |
|---|---|---|---|---|---|---|
| 1️⃣ | Nutricost Nattokinase 2,000FU (120ct) | Capsule | $0.11 | Best Overall Nattokinase | Cardiovascular health, blood flow, clean formula | Users seeking a pure, affordable, well-tested nattokinase supplement |
| 2️⃣ | Zenavea Nattokinase 2000 FU (270ct) | Capsule | $0.10 | Best High-Volume Supply | Supports circulation, heart health, clot prevention | Budget-conscious users wanting long-term use |
| 3️⃣ | Clean Nutraceuticals Nattokinase 4000 FU + Enzymes (60ct) | Capsule | $0.45 | Best Multi-Enzyme Complex | Circulation, inflammation, immune and heart support | Users seeking a comprehensive enzyme blend |
| 4️⃣ | Force Factor Nattokinase 2000 FU (90ct) | Capsule | $0.13 | Best Vegan-Friendly Formula | Blood pressure, smooth blood flow, clean label | Vegan users wanting budget-friendly cardiovascular support |
| 5️⃣ | VINATURA Nattokinase + Serrapeptase + Lumbrokinase (60ct) | Capsule | $0.40 | Best for Enzyme Synergy | Clot prevention, healthy circulation, inflammation support | Users seeking enzyme synergy with beetroot and rutin |
| 6️⃣ | Bio Absorb Nattokinase 2000 FU (60ct) | Capsule | $0.28 | Best Delayed-Release Formula | Absorption, blood flow, allergen-free formula | Sensitive users needing gentle, effective nattokinase |
| 7️⃣ | New Elements Nattokinase 4000 FU + Krill Oil (60ct) | Softgel | $0.33 | Best with Omega-3s | Heart health, DHA/EPA, circulation and joint support | Those wanting dual cardiovascular + omega-3 support |
1. Best Overall Nattokinase: Nutricost Nattokinase 2,000FU (120 Capsules)
Price: $14.95
Nutricost’s Nattokinase supplement offers 2,000 FU per capsule sourced from natto extract, delivering a clinically relevant dose in a clean, budget-friendly format. With 120 capsules per bottle, this product stands out for both affordability and quality, making it a top choice for long-term cardiovascular support.
Key Benefits
- Supports healthy blood circulation and vascular function
- May help reduce the risk of clot formation
- Can aid in maintaining normal blood pressure
- Offers antioxidant and anti-inflammatory effects for heart health
- Affordable long-term supply with easy daily dosing
Key Ingredients
- Nattokinase (from natto extract): 100 mg per capsule (2,000 FU)
- Other ingredients: Rice flour, hypromellose (vegetarian capsule)
- Free from: Gluten, GMOs, and animal products
Pros
- Provides the clinically supported 2,000 FU dose per capsule
- Third-party tested by ISO-accredited labs for purity and potency
- Vegetarian-friendly and non-GMO
- Excellent value at just ~$0.11 per capsule
- No fillers or unnecessary additives
Cons
- Contains soy (not suitable for those with soy allergies)
- No added synergistic ingredients like Vitamin K2
- Basic packaging (no extra features like time-release or blends)
Customer Feedback:
- Value for Money: Customers consistently praise this product for its low price and high quality. With 120 servings for under $15, many consider it one of the best deals in the nattokinase category.
- Effectiveness: Users report noticeable benefits, including better circulation and even blood pressure normalization after several weeks of use. One user noted their BP improved with consistent 200mg dosing.
- Ease of Use: Capsules are described as small, tasteless, and easy to swallow. Several reviews highlight the convenience of the once-daily dosage.
- Supplement Stack Friendly: Some users add it to their heart or detox stack without any side effects.
- Side Effects: No major side effects reported—well-tolerated even at double doses for some.
Best Suited For
- Adults looking for affordable and effective cardiovascular support
- Individuals wanting a straightforward nattokinase supplement without added ingredients
- Those managing blood pressure or clotting risk naturally
- Budget-conscious users needing a long-term supply
Usage Recommendations
- Take 1 capsule daily on an empty stomach (30–60 minutes before a meal or 2 hours after)
- Users with specific needs may take 2 capsules, but should consult a healthcare provider
- Not advised for those on anticoagulant therapy without doctor approval
Summary: Nutricost’s Nattokinase delivers 2,000 FU of enzyme activity per capsule in a clean, vegetarian-friendly format—making it one of the most cost-effective and reliable options for supporting circulation and cardiovascular health without unnecessary extras.
2. Best High-Volume Supply: Zenavea Nattokinase 2000 FU (270 Capsules)
Price: $29.99
Zenavea Nattokinase is a high-potency enzyme supplement designed to support cardiovascular health and healthy circulation. Each bottle contains 270 vegan capsules, providing a 9-month supply at a very competitive price. It is manufactured in the USA and formulated for adults seeking a non-GMO, gluten-free, soy-based enzyme for blood flow support.
Key Benefits
- Supports heart health and circulation by promoting fibrin breakdown
- Helps maintain healthy blood flow and vessel function
- May aid in preventing blood clots naturally
- Vegan, non-GMO, and gluten-free formulation
- Offers a 9-month supply at only $0.10 per capsule
Key Ingredients
- Nattokinase – 100 mg per capsule (2,000 FU)
- Derived from Bacillus subtilis fermentation of soy
- Capsule form; serving size: 1 capsule per day
Other ingredients: Cellulose (vegetable capsule), microcrystalline cellulose, magnesium stearate.
Note: Contains soy.
Pros
- High potency: 2,000 FU per capsule – clinically relevant dose
- Great value: 270 capsules for under $30
- Free from GMOs, gluten, dairy, eggs, and added sugar
- Manufactured in the USA under GMP standards
- Easy to swallow and digestible vegan capsules
Cons
- Contains soy, which may not be suitable for those with soy sensitivity
- Some users reported stomach discomfort if taken without food
- A few reviews questioned ingredient transparency or label accuracy
Customer Feedback:
- Value for Money: Users consistently praise its affordability, especially for a 9-month supply. Many mention it’s a great deal compared to similar products.
- Effectiveness: Reported benefits include improved circulation, reduced leg pain, and doctor-recommended results.
- Ease of Use: Most customers find it easy to swallow and appreciate the simple dosage.
- Quality Concerns: A minority of users raised doubts about the actual enzyme content and mentioned the presence of synthetic additives.
- Side Effects: Mixed experiences – while some users had no digestive issues, others experienced mild stomach discomfort, especially on an empty stomach.
Highlighted Ingredients
- Nattokinase (2,000 FU) – 100 mg per capsule
- Other ingredients: Vegetable cellulose, microcrystalline cellulose, magnesium stearate
- Soy-based (from fermented soybeans)
Best Suited For
- Adults seeking natural support for heart health and blood flow
- Individuals with leg circulation issues or clotting concerns
- Those looking for a long-term supply at an affordable price
Usage Recommendations
Take 1 capsule daily, preferably with food to minimize potential stomach discomfort. Consistency is key—best results may be seen over several weeks to months of use.
Summary: Zenavea Nattokinase offers an affordable, high-potency enzyme supplement ideal for supporting circulation and heart health. With 270 capsules and 2,000 FU per serving, it delivers strong value—though individuals sensitive to soy or seeking ultra-clean labels may want to review the ingredient list carefully.
3. Best Multi-Enzyme Complex: Clean Nutraceuticals Nattokinase 4000 FU with Serrapeptase, Lumbrokinase & Co-Factors (60 Capsules)
Price: $29.95
Clean Nutraceuticals Flow Defend is a comprehensive enzyme-based supplement designed for adults seeking cardiovascular, digestive, and inflammation-related support. With a potent blend of Nattokinase (4000 FU), Serrapeptase (120,000 SPU), Lumbrokinase, and key nutrients like Rutin, Amla, CoQ10, and Turmeric, it targets circulation, blood flow, and enzymatic health—all in just two capsules a day.
Key Benefits
- Supports healthy blood flow and circulation with high-potency fibrinolytic enzymes.
- Promotes digestive health by breaking down proteins with bromelain, papain, and papaya enzymes.
- Aids in inflammation reduction and immune defense via Turmeric, Rutin, and CoQ10.
- Combines multiple nutrients to support cardio health, energy, and oxidative balance.
- Reduces need for multiple supplements by combining diverse functions into one formula.
Key Ingredients
- Nattokinase (Glycine max) – 200 mg (4,000 FU)
- Serrapeptase – 50 mg (120,000 SPU)
- Lumbrokinase Blend – 1 mg
- Turmeric Root Extract (20:1) – 200 mg
- Rutin (Sophora japonica) – 100 mg
- Amla (Phyllanthus emblica) – 100 mg
- Bromelain + Papain + Papaya Enzymes – 119 mg proprietary blend
- CoQ10 – 10 mg
- Vitamin C (45 mg), B6 (10 mg), Calcium (30 mg), Magnesium (33 mg)
- Black Pepper Extract (95% piperine) – 5 mg
Pros
- High-potency enzymes with clinically backed doses (Nattokinase, Serrapeptase).
- Combines circulation, digestion, and immune support in one supplement.
- Manufactured in the USA by a reputable brand.
- Positive reviews on cardiovascular benefits and pain relief.
- Convenient 2-capsule daily dose.
Cons
- Some users reported headaches or stomach discomfort when taking both capsules at once.
- Capsules may be a bit strong for sensitive stomachs—splitting the dose may help.
- Return policy received minor criticism (returns not accepted if unopened).
Customer Feedback
- Value for Money: Customers feel it offers great value for the price, especially considering the number of ingredients and enzyme potency.
- Effectiveness: Many report noticeable improvements in circulation, energy, and cardio health.
- Ease of Use: Simple 2-capsule format is appreciated, and it reduces the need for multiple supplements.
- Digestive Benefits: Users praise its ability to break down heavy meals and protein.
- Pain Relief: Some say their legs hurt less or that it reduced inflammation and discomfort.
- Side Effects: A few users experienced stomach aches or headaches, particularly when taking 2 capsules at once.
Highlighted Ingredients
- Nattokinase (200 mg / 4,000 FU)
- Serrapeptase (50 mg / 120,000 SPU)
- Lumbrokinase Blend (1 mg)
- Turmeric Root Extract 20:1 (200 mg)
- Rutin (100 mg)
- Amla (100 mg)
- CoQ10 (10 mg)
- Papain & Bromelain Blend (119 mg)
- Black Pepper Extract (5 mg)
Best Suited For
- Adults seeking to support cardiovascular health and blood circulation.
- Individuals with digestive issues after high-protein meals.
- People looking to simplify their supplement stack into one powerful formula.
- Those dealing with inflammation, swelling, or mild chronic pain.
Usage Recommendations
Take 2 capsules daily, preferably with meals. For sensitive users, consider taking 1 capsule twice daily to avoid stomach upset or headaches. Stay hydrated and monitor reactions when starting.
Summary: Clean Nutraceuticals Flow Defend delivers a powerful enzyme blend with added antioxidants and nutrients, making it a strong choice for circulatory, digestive, and immune support—all in one convenient formula.
4. Best Vegan-Friendly Formula: Force Factor Nattokinase 2000 FU (90 Vegetable Capsules)
Price: $12.99
Force Factor Nattokinase delivers 2000 FU per capsule sourced from fermented soybeans. Designed to support cardiovascular and circulatory health, this supplement is ideal for adults seeking a plant-based, non-GMO option at an affordable price. Each bottle provides a 90-day supply in vegan-friendly vegetable capsules.
Key Benefits
- Promotes healthy blood flow and circulation
- Supports cardiovascular and heart function
- May help maintain normal blood pressure levels
- Provides a convenient alternative to traditional nattō
- Offers excellent value per serving
Key Ingredients
- Nattokinase (from Fermented Soybean Seed) – 2000 FU per capsule
- Form: Vegetable capsule
- Serving size: 1 capsule per day
Pros
- Budget-friendly pricing (around $0.13 per capsule)
- Non-GMO, vegan, and free from artificial flavors or gelatin
- Made in the USA in GMP-certified facilities
- 90-day supply in one bottle
Cons
- Contains soy, which may not be suitable for those with allergies
- Includes additives like magnesium stearate and silicon dioxide, which some users prefer to avoid
- Effects may vary—some users reported increased blood pressure
Customer Feedback:
- Value for Money: Many buyers praised its affordability and high dosage per serving, noting it as a cost-effective alternative to more expensive cardiovascular supplements.
- Effectiveness: Users reported improvements in blood pressure and overall energy. One user noted their blood pressure dropped to a healthy range, while another mentioned better energy levels for their elderly mother.
- Ease of Use: Customers appreciated the small, easy-to-swallow capsules and the convenience compared to eating fermented soy.
- Side Effects: A minority of users experienced negative effects, such as increased blood pressure or concerns about fillers like silicon dioxide.
- Overall Satisfaction: Most reviews were positive, highlighting its value and effectiveness, though a few users emphasized the need for ingredient transparency.
Highlighted Ingredients
- Nattokinase (from Fermented Soybean Seed) – 2000 FU
- Other ingredients: Hypromellose (capsule), Microcrystalline Cellulose, Vegetable Magnesium Stearate, Silicon Dioxide
- Contains: Soy
Best Suited For
Adults seeking natural cardiovascular support, particularly those looking for affordable daily maintenance for heart and circulation health. Also ideal for those avoiding gelatin and artificial additives.
Usage Recommendations
Take 1 capsule daily with water, preferably with a meal. Consistency is key—daily use is suggested for best results. Always consult your healthcare provider, especially if you’re on blood thinners or medication for blood pressure.
Summary: Force Factor Nattokinase offers solid heart and circulatory support at a highly affordable price. With 2000 FU per vegan capsule and made in GMP-certified U.S. facilities, it’s a great entry-level option for those exploring nattokinase supplements for blood flow and cardiovascular health.
5. Best for Enzyme Synergy: VINATURA Lumbrokinase, Nattokinase 2000FU & Serrapeptase (60 Capsules)
Price: $26.89
VINATURA Lumbrokinase Natto-Serra combines three powerful enzymes—nattokinase, serrapeptase, and lumbrokinase—formulated to promote circulation, cardiovascular health, and immune support. It is manufactured in the USA, 3rd-party lab tested, and enhanced with beet root and rutin.
Key Benefits
- Supports healthy blood flow and cardiovascular function
- May help reduce fibrin and promote cleaner arteries
- Supports immune and sinus health through serrapeptase action
- Promotes circulation without vitamin K2, ideal for those avoiding clotting interference
- Backed by quality control: GMP-certified, soy-free, dairy-free, wheat-free
Main Ingredients
- Lumbrokinase: 800,000 LU
- Nattokinase: 2,000 FU (100 mg)
- Serrapeptase: 125,000 SPU (62.5 mg)
- Proprietary blend: 100 mg Beet Root & Rutin
Form: Vegetable capsules | Serving Size: 1 capsule | Servings per container: 60
Notable Advantages
- Combines three synergistic enzymes in one formula
- No artificial fillers or common allergens (soy, tree nut, dairy, wheat)
- Made and tested in the USA under GMP standards
- Highly concentrated enzyme doses compared to competitors
Potential Drawbacks
- Higher cost per capsule compared to single-enzyme products
- Only 60 capsules per bottle, which may not last a full two months for higher dosing protocols
Customer Feedback:
- Quality: Users appreciate the USA manufacturing and third-party testing, with many calling it a “high-quality” and “excellent” product.
- Combination Value: Customers love the 3-in-1 formula, describing it as a “great combo” and “tri-supplement” with added value.
- Health Benefits: Some mention heart and circulation support, and even benefits for scar tissue and sinus issues.
- Effectiveness: Several users feel positive effects, though individual outcomes vary, as expected with enzyme-based support.
Best Suited For
This supplement is ideal for adults looking to naturally support circulation, heart health, and sinus wellness. Especially beneficial for those avoiding vitamin K2 or seeking a multi-enzyme formula in one capsule.
Usage Recommendations
Take 1 capsule daily on an empty stomach or as directed by your healthcare provider. Due to the potent enzymatic activity, start with a lower dose if you are sensitive or on medication for blood thinning.
Summary: VINATURA Lumbrokinase Natto-Serra offers a potent 3-in-1 enzyme formula designed for maximum cardiovascular and circulatory support. Made in the USA and free of common allergens, it’s a strong option for those seeking a comprehensive enzyme-based supplement.
6. Best Delayed-Release Formula: Bio Absorb Nattokinase 2000 FU (60 Veggie Capsules)
Price: $17.87
Bio Absorb Nattokinase is a professional-grade cardiovascular support supplement that delivers 100 mg of Nattokinase (2,000 FU) per capsule. Manufactured in Canada and free of common allergens, this product is designed for adults looking for a clean, effective way to support blood flow and heart health. It uses delayed-release veggie capsules for optimal absorption without harsh chemical coatings.
Key Benefits
- Supports healthy cardiovascular system function
- Promotes optimal circulation
- Delivers clinically relevant 2,000 FU per capsule
- No vitamin K2, allowing flexible dosing
- Protects enzyme activity with delayed-release technology
Key Ingredients
- Nattokinase: 100 mg (2,000 FU) – enzyme derived from non-GMO fermented soy
- Capsule: Delayed-release veggie capsule with no enteric coating or phthalates
- Free from: Gluten, dairy, nuts, animal products, and vitamin K2
Pros
- High potency dose (2,000 FU) per capsule
- K2-free for safe long-term use or stacking
- DRcaps delivery for maximum absorption
- Vegetarian and allergen-friendly
- Manufactured in Canada in a GMP-certified facility
- Third-party tested and non-irradiated
Cons
- Some complaints about excessive packaging size
- Occasional reports of seal issues in shipping
Customer Feedback
- Value for Money: Customers appreciate the affordable price and long-lasting supply options (60 to 400 capsules).
- Effectiveness: Many reviewers noted improvements in heart rhythm, circulation, and general cardiovascular function.
- Ease of Use: Capsules are described as easy to swallow, with no side effects reported in most cases.
- Side Effects: No adverse effects reported, but one customer noted poor seal quality on the packaging.
- Overall Satisfaction: Users are generally very satisfied with the purity, performance, and price.
Best Suited For
Adults looking for a vegetarian, K2-free nattokinase-only formula that supports heart and circulation health—especially those with dietary restrictions or seeking a non-GMO, allergen-free product.
Usage Recommendations
Take 1 capsule per day on an empty stomach or as directed by a healthcare provider. The delayed-release capsule ensures delivery to the small intestine, bypassing stomach acid degradation.
Summary: Bio Absorb Nattokinase offers a clean, high-potency cardiovascular enzyme supplement with 2,000 FU per capsule. Its delayed-release capsules and allergen-free formulation make it ideal for health-conscious users needing targeted heart and circulation support.
7. Best with Omega-3s: New Elements Nattokinase 4000 FU with Antarctic Krill Oil (60 Softgels)
Price: $19.99
New Elements combines two heart-friendly nutrients—Nattokinase and Antarctic Krill Oil—into one powerful formula designed to support cardiovascular circulation, reduce inflammation, and boost overall energy. Each bottle contains 60 softgels (30 servings), delivering 2000 mg of krill oil and 4000 FU of nattokinase per daily dose.
Key Benefits
- Promotes healthy blood flow and circulation
- Supports heart health with high-potency nattokinase (4000 FU)
- Delivers omega-3 fatty acids (DHA & EPA) for brain, joint, and skin support
- Helps reduce inflammation naturally
- May improve energy and mental clarity
Key Ingredients
- Nattokinase (2000 FU per softgel, 4000 FU per serving)
- Krill Oil (2000 mg per serving)
- Omega-3s including EPA (264 mg) and DHA (103.8 mg)
- Serving size: 2 softgels per day
Pros
- Combines two potent cardiovascular ingredients in one formula
- High EPA/DHA content supports multiple systems beyond the heart
- Easy-to-swallow softgels with no fishy aftertaste
- Non-GMO, sugar-free, no artificial ingredients
- GMP-certified manufacturing
Cons
- Not labeled as third-party tested, which may concern cautious users
- Contains bovine gelatin (not suitable for vegetarians)
- Some users noted the presence of titanium dioxide (a controversial additive)
- Capsules are slightly large for some users
Customer Feedback
- Effectiveness: Users widely report improved circulation, boosted energy levels, and overall heart health. Many mention noticeable benefits like better skin and mental clarity.
- Omega-3 Benefits: Customers appreciate the strong DHA & EPA content and report reduced joint pain and inflammation.
- Ease of Use: Despite the large size, most users say the softgels are smooth and easy to swallow with no aftertaste.
- Concerns: A few users flagged the lack of third-party testing and inclusion of titanium dioxide as potential drawbacks.
Best Suited For
Ideal for adults looking for a dual-action supplement to improve cardiovascular health, enhance omega-3 intake, and support circulation and energy in one convenient product.
Usage Recommendations
Take 2 softgels daily with food or as directed by your healthcare provider. Do not exceed more than 2 softgels within 24 hours. Store in a cool, dry place.
Summary: This 2-in-1 supplement blends high-potency nattokinase (4000 FU) with 2000 mg of krill oil for heart, circulation, and anti-inflammatory support. It’s a great option for those who want cardiovascular and omega-3 benefits in one product.
What is Nattokinase?
Nattokinase is a fibrinolytic enzyme extracted from natto, a fermented soybean dish commonly consumed in Japan. It was first discovered by Dr. Hiroyuki Sumi in the 1980s, who found that nattokinase could dissolve blood clots in a lab setting.
Unlike many blood-thinning medications that come with a long list of side effects, nattokinase works naturally by breaking down fibrin, a protein involved in clot formation. This makes it an appealing option for people seeking a natural approach to support cardiovascular function.
Health Benefits of Nattokinase
Research and clinical evidence suggest several key benefits from taking nattokinase regularly:
- Supports healthy blood circulation: Helps break down fibrin and reduce blood viscosity, improving flow.
- Promotes heart health: May assist in maintaining healthy blood pressure and reducing strain on the cardiovascular system.
- Natural blood-thinning support: Without the harsh effects of prescription anticoagulants, nattokinase may help reduce clot risk.
- May assist in lowering blood pressure: Some studies have shown nattokinase can reduce systolic and diastolic blood pressure over time.
- Anti-inflammatory potential: Nattokinase has shown possible anti-inflammatory effects that benefit vascular health.
How to Choose the Best Nattokinase Supplement
When shopping for a nattokinase supplement, here are the most important factors to consider:
- Standardized Activity (FU): Look for supplements labeled with at least 2,000 FU (Fibrinolytic Units) per serving – the clinically effective dose.
- Purity and source: Products sourced from non-GMO soy and manufactured under GMP-certified facilities are ideal.
- Additives and formulation: Some supplements combine nattokinase with vitamin K2 or other heart-supporting ingredients. Choose based on your personal health goals.
- Vegan-friendly options: If you follow a plant-based lifestyle, confirm whether the capsule is vegan.
- Third-party tested: Opt for brands that provide independent lab testing for quality and potency.
Who Should Consider Nattokinase?
Nattokinase is best suited for individuals who:
- Want to support heart and vascular health naturally
- Are concerned about circulatory issues like poor blood flow, cold hands and feet, or high fibrin levels
- Seek a natural alternative to low-dose aspirin or blood-thinners
- Want to manage mild blood pressure elevations or support after vascular procedures (under medical supervision)
Usage Recommendations
Most nattokinase supplements provide 100–200 mg per serving, standardized to 2,000 FU. For best results:
- Take on an empty stomach (30–60 minutes before meals or 2 hours after eating)
- Do not combine with other blood-thinning medications unless under supervision
- Stick to 1–2 capsules daily, depending on the brand’s recommendation
FAQs about Nattokinase
When is the best time to take nattokinase?
On an empty stomach—either first thing in the morning or before bedtime for optimal absorption.
Is it safe to take nattokinase long-term?
For most healthy individuals, yes. However, those with bleeding disorders or on anticoagulants should consult a doctor.
How long does it take to see results?
Some users report improved circulation or blood pressure within 4–8 weeks of consistent use.
Can nattokinase replace blood pressure or blood thinner medications?
No. It can be a supportive supplement but should never replace prescribed drugs without physician approval.
Are there side effects?
Nattokinase is generally well tolerated. Rarely, users may experience dizziness or light bruising.
Final Verdict
Nattokinase offers a natural, research-backed option for supporting heart and circulatory health. Whether you’re managing mild hypertension, looking to improve blood flow, or supporting cardiovascular wellness as you age, adding a high-quality nattokinase supplement to your routine could be a smart move—especially when paired with a healthy lifestyle.