Best 6 Serrapeptase Supplements for Inflammation Relief

Serrapeptase is gaining attention as a natural enzyme with powerful anti-inflammatory and mucus-clearing properties. Originally discovered in the digestive tract of silkworms, this proteolytic enzyme has been used in Europe and Asia for decades to support sinus health, reduce swelling, and aid in post-surgical recovery. Whether you’re looking to ease chronic inflammation, improve circulation, or clear sinus congestion, serrapeptase supplements may offer surprising benefits.

In this guide, we’ll explain what serrapeptase is, how it works, and what to look for in a high-quality supplement. We’ll also review the top 6 serrapeptase supplements on the market once our product list is finalized.

Our Top Picks for Serrapeptase Supplements

1. Best Overall Serrapeptase: Zazzee Delayed Release Serrapeptase 120,000 SPU (120 Capsules)

• Why? Offers 120,000 SPU per capsule in vegan-friendly, delayed-release capsules to enhance absorption. Non-GMO, all-natural, and delivers excellent value with a full 4-month supply per bottle.
• Key Benefits: Supports sinus health, inflammation reduction, and systemic enzyme activity.
• Best for: Users seeking a high-quality, long-lasting serrapeptase supplement with clean ingredients and optimized absorption.

2. Best Budget Serrapeptase: Nutricost Serrapeptase 120,000 SPU (120 Capsules)

• Why? Delivers the same 120,000 SPU potency as top competitors but at a significantly lower price point. Gluten-free, non-GMO, and third-party tested.
• Key Benefits: Supports tissue repair, inflammation reduction, and immune modulation.
• Best for: Budget-conscious users who still want effective dosage and clean formulation.

3. Best High-Potency Serrapeptase: Double Wood Serrapeptase 240,000 SPU (120 Capsules)

• Why? Offers a potent 240,000 SPU per serving with two capsules, ideal for users needing intensive support. Vegan, non-GMO, and third-party tested for purity.
• Key Benefits: Helps reduce mucus, supports joint recovery, and promotes immune balance.
• Best for: Individuals requiring a stronger systemic enzyme dosage for chronic issues or advanced support.

4. Best for Maximum Supply: Bio Absorb Serrapeptase 120,000 SPU (200 Capsules)

• Why? Offers a massive 200-day supply in delayed-release DRcaps without phthalates, enhancing absorption while avoiding harsh additives.
• Key Benefits: Promotes enzyme stability, reduces inflammation, and supports digestive and immune health.
• Best for: Long-term users looking for clean-label supplements with high daily activity and value.

5. Best Vegan Enzyme Complex: MaryRuth Organics Serrapeptase Systemic Enzymes (60 Capsules)

• Why? Combines serrapeptase with protease, vitamins, and minerals for systemic enzyme support. Pine-derived vegan capsules, allergen-free, and non-GMO.
• Key Benefits: Supports immune balance, tissue healing, and overall systemic health.
• Best for: Users looking for a broader enzyme blend with added micronutrient cofactors in a vegan formula.

6. Best Value for High Potency: Vitamatic Serrapeptase 240,000 SPU (120 Capsules)

• Why? Delivers 240,000 SPU per 2-capsule serving at just $0.11 per count—one of the best values for high-dose serrapeptase. Enteric-coated DRcaps protect enzyme activity.
• Key Benefits: Aids joint mobility, sinus relief, and digestive support.
• Best for: Users seeking strong potency at the lowest cost per capsule.

Rank	Product	Form	Price per Count	Highlight	Key Benefits	Best For
1️⃣	Zazzee Delayed Release Serrapeptase 120,000 SPU (120ct)	Capsule	$0.25	Best Overall Serrapeptase	Sinus health, inflammation reduction, systemic enzyme activity	Users seeking a clean, high-quality long-term enzyme supplement
2️⃣	Nutricost Serrapeptase 120,000 SPU (120ct)	Capsule	$0.14	Best Budget Serrapeptase	Tissue repair, inflammation control, immune modulation	Budget-conscious users wanting effective systemic support
3️⃣	Double Wood Serrapeptase 240,000 SPU (120ct)	Capsule	$0.15	Best High-Potency Serrapeptase	Reduce mucus, joint recovery, immune balance	Individuals needing a high-potency systemic enzyme dose
4️⃣	Bio Absorb Serrapeptase 120,000 SPU (200ct)	Capsule	$0.27	Best for Maximum Supply	Enzyme stability, inflammation support, immune health	Long-term users wanting allergen-free daily support
5️⃣	MaryRuth Organics Serrapeptase Systemic Enzymes (60ct)	Capsule	$0.37	Best Vegan Enzyme Complex	Immune balance, tissue healing, systemic support	Users preferring a complex formula with added nutrients
6️⃣	Vitamatic Serrapeptase 240,000 SPU (120ct)	Capsule	$0.11	Best Value for High Potency	Joint mobility, sinus relief, digestive support	Users wanting strong potency at lowest price per count

1. Best Overall Serrapeptase: Zazzee Delayed Release Serrapeptase 120,000 SPU (120 Capsules)

Price: $29.97

Zazzee Extra Strength Serrapeptase stands out as one of the most potent and clean formulations on the market. Each capsule delivers a high dose of 120,000 SPU in a delayed-release, vegan capsule designed for maximum absorption. With 120 capsules per bottle, it offers a 4-month supply, making it an excellent value for long-term inflammation and sinus support.

Key Benefits

• Promotes pain relief and muscle recovery
• Supports sinus and respiratory health
• Helps dissolve unwanted proteins like fibrin and mucus
• May aid in post-surgical healing and scar reduction
• Enhances immune and circulatory function

What It Contains

• Serrapeptase (Serratiopeptidase): 120,000 SPU per capsule
• Form: Delayed-release vegan capsules
• Other Ingredients: Rice powder, hypromellose, magnesium stearate (vegetable source), silica
• Free from gluten, soy, dairy, GMOs, and common allergens

Pros

• High-potency dose per capsule (120,000 SPU)
• Delayed-release for better enzyme survival in digestion
• Non-GMO, vegan-friendly, and allergen-free
• Made in a GMP-certified, lab-tested facility in the USA
• 4-month supply at a competitive price

Cons

• May be too strong for beginners (start with lower dose if sensitive)
• Some users reported mild bloating or temporary discomfort when first starting

Customer Feedback:

• Pain Relief: Many users report significant relief from joint pain, low back pain, and fibrocystic breast discomfort. One noted improved breathing and reduced clot risk.
• Effectiveness: Widely praised for working “from the inside,” with users noticing reduced mucus and smoother breathing. Some even compare its results favorably to medical-grade humidifiers.
• Ease of Use: Capsules are small, easy to swallow, and tasteless, making them ideal for daily use.
• Respiratory Benefits: Users say it cleared lungs and helped them breathe easier, especially at night.
• Potential Side Effects: A few users reported temporary side effects like bloating, fluid retention, headaches, or nausea—mostly when taken at full strength too soon.
• Strength: Some reviewers found the formula too potent initially, causing weakness or minor allergic reactions.

Best Suited For

• Adults dealing with chronic inflammation, pain, or sinus congestion
• Individuals recovering from injury or surgery
• People with respiratory issues or mucous buildup
• Those needing a high-potency, all-natural systemic enzyme supplement

Usage Recommendations
Take 1 capsule daily on an empty stomach, at least 30 minutes before eating or 2 hours after a meal. Start with a lower dose (e.g., every other day) if you’re new to serrapeptase, then gradually build up.

Summary: Zazzee Extra Strength Serrapeptase offers top-tier potency, clean ingredients, and delayed-release technology in a vegan-friendly capsule. With excellent user feedback and a generous 4-month supply, it’s a trusted choice for those seeking long-term relief from inflammation, sinus issues, or protein buildup in the body.

2. Best Budget Serrapeptase: Nutricost Serrapeptase 120,000 SPU (120 Capsules)

Price: $17.95

Nutricost Serrapeptase is a no-frills, high-potency option for those seeking an affordable way to try serrapeptase. Each capsule delivers 120,000 SPU of serratiopeptidase, and with 120 capsules per bottle, it provides up to four months of daily use. This supplement is gluten-free, vegetarian-friendly, non-GMO, and third-party tested—making it a clean and cost-effective option.

Key Benefits

• Supports blood cleansing and healthy circulation
• Helps with joint and tissue inflammation
• May assist in sinus relief and clearer airways
• Anti-inflammatory properties for general well-being
• A budget-friendly option for long-term use

What It Contains

• Serrapeptase: 120,000 SPU per capsule (60 mg)
• Form: Regular vegetable capsule (not enteric-coated)
• Other Ingredients: Rice flour, hypromellose (vegetable capsule), maltodextrin
• Free from gluten and GMOs

Pros

• High potency at a very competitive price (as low as $0.12 per capsule)
• Vegetarian and gluten-free
• Clean formula with minimal fillers
• Third-party tested by ISO-accredited labs
• Great for budget-conscious users looking for high SPU

Cons

• Not enteric-coated – enzyme may be destroyed by stomach acid
• Some users say effectiveness is reduced without proper coating
• Lacks added absorption enhancers or protective delivery system

Customer Feedback:

• Effectiveness: Users describe it as “high quality” and “it works great,” especially for joint support and circulation. However, some note that coating may affect results.
• Value for Money: Highly praised as “cost-effective” and “cheaper for the dosage,” especially compared to other high-SPU products.
• Blood Cleansing: Many report benefits like anti-inflammatory effects, artery support, and cleaner blood function.
• Enteric Coating Concerns: Several users highlight the lack of enteric coating, with concerns that it may lower bioavailability due to stomach acid breakdown.

Best Suited For

• Budget-conscious shoppers
• Individuals already familiar with serrapeptase and want to increase dosage
• People looking for blood-cleansing and cardiovascular enzyme support

Usage Recommendations
Take 1 capsule per day on an empty stomach (at least 30 minutes before or 2 hours after a meal). Because this product is not enteric-coated, consider pairing it with food that reduces stomach acidity, or take it with a pH buffer if sensitive.

Summary: Nutricost Serrapeptase delivers high potency at a fraction of the price, making it ideal for long-term use or those on a budget. While it lacks an enteric coating, users still report noticeable benefits for inflammation and circulation.

3. Best High-Potency Serrapeptase: Double Wood Serrapeptase 240,000 SPU (120 Capsules)

Price: $19.95

Double Wood’s Serrapeptase supplement is ideal for those looking for maximum potency in each serving. With 240,000 SPU per 2-capsule dose, it delivers one of the highest enzyme strengths available on the market. Each bottle contains 120 capsules (60 servings), offering a strong 2-month supply. It’s vegan, gluten-free, and made in the USA with third-party testing to ensure purity and potency.

Key Benefits

• High-strength support for inflammation and pain relief
• Helps reduce mucus and sinus congestion
• Promotes cardiovascular and blood flow health
• Supports digestive and immune system function
• May help smooth skin and reduce scar tissue

What It Contains

• Serrapeptase: 240,000 SPU per 2-capsule serving
• Form: Regular vegetarian capsule (no enteric coating)
• Other Ingredients: Hypromellose (capsule), rice flour, magnesium stearate, silicon dioxide
• Allergen Warning: Contains soy and milk

Pros

• Very high dose (240,000 SPU per serving)
• Made in GMP-certified, USA-based facility
• Third-party tested for quality and safety
• Positive feedback for pain, blood flow, and scar reduction
• Only $0.15 per capsule — good value for such high potency

Cons

• Not enteric-coated — potential for reduced absorption in stomach acid
• May not be suitable for those avoiding soy or dairy
• Some users experienced limited results due to coating issue

Customer Feedback:

• Effectiveness: Customers repeatedly note that it “works well,” especially for inflammation, sinus issues, and general healing.
• Pain Relief: Widely praised for reducing nerve and joint pain, post-surgical soreness, and improving scar tissue healing.
• Digestive Function: Some reported better digestion and fewer growths or discomfort in the abdominal area.
• Value for Money: Most users agree it offers “fair price” and great effectiveness per dollar.
• Blood Flow: Users noticed improvements in plaque breakdown, blood clot resolution, and artery health.
• Skin Elasticity: Positive feedback for fading scars and improving skin texture, especially on old tissue.
• Enteric Coating: A common concern; many mentioned it lacks protection from stomach acid, which might limit effectiveness.

Best Suited For

• Users looking for maximum serrapeptase potency
• Those with chronic inflammation, scarring, or circulatory issues
• People experienced with serrapeptase who can tolerate stronger doses
• Budget buyers seeking high-value, high-strength supplements

Usage Recommendations
Take 2 capsules per day on an empty stomach, ideally 30 minutes before a meal or 2 hours after eating. Due to the lack of enteric coating, consider splitting the dose and monitoring tolerance early on.

Summary: Double Wood Serrapeptase delivers one of the highest potencies available, with strong user feedback for pain relief, digestion, circulation, and skin healing. While it lacks enteric coating, the strength and value make it a go-to choice for experienced users.

4. Best for Maximum Supply: Bio Absorb Serrapeptase 120,000 SPU (200 Capsules)

Price: $57.77

BioAbsorb Nutraceuticals offers a professional-grade serrapeptase supplement featuring 120,000 SU per capsule in a bonus-size 200-count bottle. It’s designed with patented DRcaps delayed-release capsules to ensure optimal absorption by protecting the enzyme from stomach acid.

Key Benefits

• Supports pain relief, especially joint and muscle aches
• Promotes healthy inflammatory response and healing
• Enhances blood flow and may help clear arterial plaque
• Improves sleep quality and overall vitality
• Suitable for long-term systemic enzyme therapy

Key Ingredients

• Serrapeptase: 120,000 SU per capsule
• Other ingredients: Brown rice flour, magnesium stearate, cellulose-based DRcaps

Pros

• Delayed-release DRcaps protect enzyme activity
• High potency (120,000 SU per capsule)
• Clean label: Non-GMO, vegetarian, gluten-free, nut-free, and dairy-free
• Made in Canada and 3rd party tested
• 200-day supply offers great convenience

Cons

• Higher price per bottle compared to most competitors
• Some users report mild digestive discomfort or uncertain results
• Mixed reviews on effectiveness vs. expectations

Customer Feedback:

• Pain Relief:
  Users frequently noted relief from inflammation, improved joint comfort, and even better sleep. Some reported sinus and pelvic floor benefits.
• Effectiveness:
  Majority agree it “actually works” and helps with pain and swelling. A few say it outperforms other brands they’ve tried.
• Value for Money:
  Mixed opinions—some feel it’s a great value for 200 capsules, while others think the effects don’t justify the price.
• Artery Cleaning:
  Positive but limited feedback on cardiovascular benefits like dissolving fibrin and clearing artery buildup.

Best Suited For

• Adults looking for an enteric-protected enzyme
• People with chronic inflammation, sinus issues, or cardiovascular concerns
• Health-conscious users wanting allergen-friendly, clean-label supplements

Usage Recommendations
Take 1 capsule daily on an empty stomach (at least 30 minutes before or 2 hours after meals) for best results. The delayed-release capsule enhances bioavailability.

Summary: BioAbsorb Serrapeptase is ideal for users seeking a high-quality, stomach-acid-resistant enzyme supplement. While the price is higher, the delayed-release DRcaps and allergen-free formula make it a top choice for sensitive users.

5. Best Vegan Enzyme Complex: MaryRuth Organics Serrapeptase Systemic Enzymes (60 Capsules)

Price: $24.95

MaryRuth Organics offers a serrapeptase supplement designed with a blend of enzymes, vitamins, and minerals aimed at supporting cellular, immune, and tissue health. Each capsule contains 120,000 SPU of enteric-coated serrapeptase and is crafted for systemic use—taken on an empty stomach for best absorption. It’s vegan, corn-derived, and suitable for sensitive individuals.

Key Benefits

• Supports immune function, tissue repair, and cellular health
• Aids sinus relief and respiratory comfort
• Promotes protein breakdown and inflammation control
• Gentle on the stomach thanks to enteric-coated enzyme blend
• Ideal for individuals avoiding common allergens (gluten, soy, dairy)

Main Ingredients

• Serrapeptase (Enteric-coated, 120,000 SPU)
• Protease (85,000 HUT)
• Enzyme-enhancing vitamins: B1, B6, B12, Calcium, Magnesium, Manganese
• Amla and Phytase for additional enzyme support
• Pine-derived vegan capsule

Notable Advantages

• Enteric coating protects the enzyme from stomach acid
• Enzyme-enhancing vitamins help boost systemic absorption
• Pine-derived capsules and vegan-friendly formula
• Produced by a trusted brand known for clean-label supplements

Potential Drawbacks

• Higher price point at $0.37 per capsule
• Some users report stomach discomfort or queasiness
• Contains corn-derived maltodextrin, which may be a concern for some

Customer Feedback

Effectiveness:
Customers find it highly effective for inflammation, pain relief, and sinus issues. Many say it works better than OTC painkillers.

Quality:
Generally regarded as a high-quality formula, with users appreciating the ingredient transparency and vegan integrity.

Enzyme Content:
Praised for its potent enzyme blend, particularly the inclusion of protease and serrapeptase in meaningful doses.

Sinus Relief:
Multiple reviewers report eased nasal breathing, reduced mucus, and better sinus drainage.

Vitamin Content:
The B-vitamin mix is seen as a plus, supporting cellular energy and immune health.

Ease of Swallowing:
Users appreciate that the capsules are small and odorless, making them easy to take daily.

Value for Money:
Mixed feedback—some feel it’s worth the cost, while others think it’s pricey for a 60-count bottle.

Side Effects (Pain Level):
13 users mentioned stomach-related issues like nausea, queasiness, or diarrhea—possibly from sensitivity to enzymes or the corn-derived ingredient.

Highlighted Ingredients (Per Capsule)

• Serrapeptase (enteric-coated): 120,000 SPU
• Proteases: 85,000 HUT
• Thiamine (B1): 0.33 mg
• Vitamin B6: 0.33 mg
• Vitamin B12: 0.66 mcg
• Calcium: 0.9 mg
• Magnesium: 0.9 mg
• Manganese: 0.2 mg
• Amla: 2 mg
• Phytase: 5 mg

Best Suited For

• Individuals seeking a gentle-on-the-stomach enzyme
• Those with sinus congestion, inflammatory issues, or digestive imbalance
• Health-conscious consumers wanting non-GMO, vegan, and clean-label supplements

Usage Recommendations

Take 1 capsule daily, ideally 30-60 minutes before or 2 hours after a meal. Best when taken on an empty stomach with water for systemic benefits.

Summary: MaryRuth’s Serrapeptase offers a unique enzyme and vitamin blend, with enteric-coated protection and high-quality ingredients. It’s especially valuable for those needing multi-system enzyme support and sensitive digestion, though the price may be a concern for some.

6. Best Value for High Potency: Vitamatic Serrapeptase 240,000 SPU (120 Capsules)

Price: $14.99

Vitamatic Serrapeptase delivers a powerful 240,000 SPU per serving in DRcaps designed to survive stomach acid. Made in the USA, it targets joint, sinus, and respiratory support. It’s especially notable for being one of the most affordable high-potency serrapeptase supplements on the market.

Key Benefits

• Provides potent 240,000 SPU per 2-capsule serving
• Supports joint, sinus, and respiratory health
• Formulated with delayed-release DRcaps for optimal enzyme absorption
• Budget-friendly with 120 capsules per bottle
• Made in a GMP-certified, FDA-registered facility

Main Ingredients

• Serrapeptase: 240,000 SPU per serving (2 capsules)
• DRcaps® hypromellose capsule designed to bypass stomach acid
• Other ingredients: Microcrystalline cellulose, vegetable magnesium stearate, silicon dioxide

Notable Advantages

• High potency dose for enhanced systemic support
• Excellent price per count ($0.11)
• Non-GMO, gluten-free, and free of artificial additives
• Manufactured in the USA in GMP-compliant conditions

Potential Drawbacks

• Contains soy and milk, which may not suit individuals with allergies
• Some users did not notice significant changes after short-term use

Customer Feedback

• Value for Money: Users consistently mention it as a top-value product, especially for its high potency at a very low cost.
• Quality: Reviews highlight the solid quality and packaging, with zero negative comments.
• Potency: Customers are impressed with the strong dosage, stating it works well and offers noticeable benefits.
• Effectiveness: Some users feel it works well, but others report no significant changes, likely due to the need for longer-term use.

Best Suited For

• Budget-conscious individuals seeking a high-potency serrapeptase
• Those aiming to support joint, sinus, or respiratory health
• Users preferring delayed-release capsules for better enzyme survival

Usage Recommendations

Take 2 capsules daily on an empty stomach, or as directed by a healthcare professional. Best taken 30–60 minutes before or 2 hours after meals.

Summary: Vitamatic Serrapeptase offers a highly potent 240,000 SPU dose per serving at one of the lowest prices on the market. Its delayed-release formula and GMP-certified production make it a strong choice for those prioritizing affordability and performance.

What Is Serrapeptase?

Serrapeptase (also known as serratiopeptidase) is a systemic enzyme that breaks down non-living tissue, mucus, blood clots, and inflammatory proteins in the body. Unlike digestive enzymes that work only in the gut, serrapeptase is absorbed into the bloodstream and travels throughout the body to target unwanted protein buildup.

Originally isolated from the bacteria Serratia marcescens found in silkworms, serrapeptase helps the silkworm dissolve its cocoon. Today, it’s produced through fermentation and commonly used as a natural remedy for inflammation, sinus congestion, and pain.

Top Benefits of Serrapeptase

Many users turn to serrapeptase for its wide range of health benefits, including:

• Reducing inflammation and swelling from injuries, arthritis, or surgery
• Relieving sinus congestion by breaking down excess mucus
• Improving circulation by dissolving fibrin, a protein involved in clotting
• Promoting faster healing after surgery or dental procedures
• Alleviating pain from conditions like carpal tunnel, fibrocystic breast disease, or varicose veins

Several small studies and user experiences support its use, though more large-scale research is still needed.

How We Ranked the Best Serrapeptase Supplements

To identify the best serrapeptase supplements, we focused on these key criteria:

• Potency: Effective products typically provide between 40,000 IU and 120,000 IU per serving.
• Enteric Coating: Since serrapeptase can be broken down by stomach acid, a delayed-release (enteric-coated) capsule is crucial to ensure absorption in the small intestine.
• Purity and Quality: We prefer products free from artificial fillers, GMO-free, and manufactured in GMP-certified facilities.
• User Feedback: Real-world experiences help highlight how well the product performs over time.
• Value: We looked at cost per serving and overall value for long-term use.

Who Should Use Serrapeptase?

Serrapeptase is typically used by people seeking natural inflammation relief or support for respiratory health and tissue repair. You may benefit from serrapeptase if you:

• Suffer from chronic sinus congestion
• Are recovering from surgery, injury, or trauma
• Experience joint pain or stiffness from arthritis
• Want to support cardiovascular health by improving blood flow
• Struggle with fibrocystic breasts or internal scarring

Always consult your healthcare provider before starting serrapeptase, especially if you’re on blood-thinning medications.

Possible Side Effects and Safety

Serrapeptase is generally well-tolerated when taken as directed. However, some users may experience:

• Minor digestive discomfort (bloating, nausea)
• Increased bleeding risk if taken with anticoagulants
• Allergic reactions (rare)

To reduce the risk of side effects, always take serrapeptase on an empty stomach, and follow dosing instructions carefully.

How to Take Serrapeptase for Best Results

For optimal results, follow these best practices:

• Timing: Take on an empty stomach—at least 2 hours after a meal and wait 30 minutes before eating again.
• Dosage: Most effective doses range from 40,000 IU to 120,000 IU daily, depending on the condition.
• Consistency: Daily use is often necessary for chronic conditions; some effects may take a few weeks to notice.
• Form: Choose enteric-coated capsules for better absorption in the intestines.

Frequently Asked Questions (FAQ)

Final Verdict

Serrapeptase is a powerful enzyme that offers natural, drug-free relief from inflammation, sinus congestion, and tissue damage. Choosing the right supplement—especially one with enteric coating and proper potency—can make all the difference.

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